Reactome | MET receptor recycling

MET receptor recycling

Stable Identifier

R-HSA-8875656

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Activated MET receptor is subject to recycling from the plasma membrane through the endosomal compartment and back to the plasma membrane (Peschard et al. 2001, Hammond et al. 2001, Petrelli et al. 2002). In the recycling process, activated MET receptor is endocytosed, and the GGA3 protein directs it, via a largely unknown mechanism, through the RAB4 positive endosomal compartments back to the plasma membrane (Parachoniak et al. 2011). Endosomal signaling by MET during the recycling process appears to play an important role in sustained activation of ERK1/ERK2 (MAPK3/MAPK1) and STAT3 downstream of MET (Kermorgant and Parker 2008).

Literature References

PubMed ID	Title	Journal	Year
18779368	Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation Kermorgant, S, Parker, PJ	J. Cell Biol.	2008
11894096	The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met Petrelli, A, Gilestro, GF, Lanzardo, S, Comoglio, PM, Migone, N, Giordano, S	Nature	2002
11420688	Down-regulation of MET, the receptor for hepatocyte growth factor Hammond, DE, Urbé, S, Vande Woude, GF, Clague, MJ	Oncogene	2001
21664574	GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration Parachoniak, CA, Luo, Y, Abella, JV, Keen, JH, Park, M	Dev. Cell	2011
11741535	Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein Peschard, P, Fournier, TM, Lamorte, L, Naujokas, MA, Band, H, Langdon, WY, Park, M	Mol. Cell	2001