RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane

Stable Identifier
R-HSA-8875659
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
recycling endosome membrane, plasma membrane
ReviewStatus
5/5
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RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane
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RAB4 is needed for recycling of the activated MET receptor complex (Parachoniak et al. 2011).

Literature References
PubMed ID Title Journal Year
21664574 GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration

Abella, JV, Park, M, Luo, Y, Parachoniak, CA, Keen, JH

Dev. Cell 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
GGC-RAB4:GTP [recycling endosome membrane] (Homo sapiens)
Orthologous Events
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Bos taurus)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Caenorhabditis elegans)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Canis familiaris)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Danio rerio)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Gallus gallus)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Mus musculus)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Rattus norvegicus)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Sus scrofa)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Birchmeier, W  (2016-07-11)
Heynen, G  (2016-07-11)
Created
Orlic-Milacic, M  (2016-06-08)
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