Reactome | GGA3 associates with activated MET receptor

GGA3 associates with activated MET receptor

Stable Identifier

R-HSA-8875661

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

plasma membrane, recycling endosome membrane

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GGA3 associates with activated MET receptor

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GGA3 associates with the activated MET receptor through the CRK adapter and the ARF6:GTP complex and co-localizes with the MET receptor at early endosome membranes. The mechanistic details of GGA3 recruitment to MET have not been elucidated. GGA3 promotes recycling of the activated MET receptor through a RAB4-positive endosomal compartment (Parachoniak et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21664574	GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration Parachoniak, CA, Luo, Y, Abella, JV, Keen, JH, Park, M	Dev. Cell	2011