GGA3 associates with the activated MET receptor through the CRK adapter and the ARF6:GTP complex and co-localizes with the MET receptor at early endosome membranes. The mechanistic details of GGA3 recruitment to MET have not been elucidated. GGA3 promotes recycling of the activated MET receptor through a RAB4-positive endosomal compartment (Parachoniak et al. 2011).
Parachoniak, CA, Luo, Y, Abella, JV, Keen, JH, Park, M
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