MBTPS1 (S1P) cleaves CREB3L1

Stable Identifier
Reaction [transition]
Homo sapiens
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In the Golgi membrane, CREB3L1 (OASIS) is cleaved in its lumenal domain (Denard et al. 2011, Denard et al. 2012, Mellor et al. 2013, Rose et al. 2014, Ward et al. 2016) by MBTPS1 (S1P) (Denard et al. 2012, inferred from mouse homologs). By inference from SREBFs (SREBPs) and other CREB3 family proteins, CREB3L1 is cleaved at an RSLL motif around amino acid residue 426.
Literature References
PubMed ID Title Journal Year
21767813 The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cells

Chen, Q, Gay, A, Chen, Y, Denard, B, Huang, H, Seemann, J, Ye, J

Cell Host Microbe 2011
24126059 CREB3L1 is a metastasis suppressor that represses expression of genes regulating metastasis, invasion, and angiogenesis

Carlsen, SA, Calvert, B, Anderson, DH, Deibert, L, Bonham, K, Mellor, P

Mol. Cell. Biol. 2013
23256041 Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1

Denard, B, Lee, C, Ye, J

Elife 2012
26810754 Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers

Sarker, S, Anderson, DH, Smith, SE, Kendall, S, Just, NA, Carlsen, SA, Saxena, A, Alvi, R, Ward, AK, Phillips, Z, Vizeacoumar, FS, Mellor, P, Vizeacoumar, FJ

Breast Cancer Res. 2016
25625847 OASIS/CREB3L1 is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migration in vitro

Dahl, E, Heer, M, Dierichs, L, Schubert, C, Rose, M, Heidenreich, A, Knuchel, R, Gaisa, NT

Epigenetics 2014
Catalyst Activity

serine-type endopeptidase activity of MBTPS1 [Golgi membrane]

Inferred From
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