MBTPS1 (S1P) cleaves CREB3L1

Stable Identifier
R-HSA-8874212
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the Golgi membrane, CREB3L1 (OASIS) is cleaved in its lumenal domain (Denard et al. 2011, Denard et al. 2012, Mellor et al. 2013, Rose et al. 2014, Ward et al. 2016) by MBTPS1 (S1P) (Denard et al. 2012, inferred from mouse homologs). By inference from SREBFs (SREBPs) and other CREB3 family proteins, CREB3L1 is cleaved at an RSLL motif around amino acid residue 426.

Literature References
PubMed ID Title Journal Year
24126059 CREB3L1 is a metastasis suppressor that represses expression of genes regulating metastasis, invasion, and angiogenesis

Mellor, P, Deibert, L, Calvert, B, Bonham, K, Carlsen, SA, Anderson, DH

Mol. Cell. Biol. 2013
21767813 The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cells

Denard, B, Seemann, J, Chen, Q, Gay, A, Huang, H, Chen, Y, Ye, J

Cell Host Microbe 2011
23256041 Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1

Denard, B, Lee, C, Ye, J

Elife 2012
26810754 Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers

Ward, AK, Mellor, P, Smith, SE, Kendall, S, Just, NA, Vizeacoumar, FS, Sarker, S, Phillips, Z, Alvi, R, Saxena, A, Vizeacoumar, FJ, Carlsen, SA, Anderson, DH

Breast Cancer Res. 2016
25625847 OASIS/CREB3L1 is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migration in vitro

Rose, M, Schubert, C, Dierichs, L, Gaisa, NT, Heer, M, Heidenreich, A, Knuchel, R, Dahl, E

Epigenetics 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of MBTPS1 [Golgi membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created