Mbtps1 (S1P) cleaves Creb3l1 (Oasis)

Stable Identifier
R-MMU-8874394
Type
Reaction [transition]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Mbtps1 (S1P) cleaves Creb3l1 (Oasis)
In the Golgi membrane Creb3l1 (Oasis) is cleaved in its lumenal domain (Kondo et al. 2012) by Mbtps11 (S1P) (Kondo et al. 2005, Murakami et al. 2006). By inference with SREBFs (SREBPs) and other CREB3 family proteins, Creb3l1 is believed to be cleaved at an RSLL motif around amino acid residue 426.
Literature References
PubMed ID Title Journal Year
22705851 Activation of OASIS family, ER stress transducers, is dependent on its stabilization

Iwamoto, H, Hino, SI, Oki, M, Nomura, Y, Miyagi, H, Urano, F, Saito, A, Kaneko, M, Izumi, S, Imaizumi, K, Kawasaki, N, Kanemoto, S, Kondo, S, Asada, R

Cell Death Differ. 2012
16417584 Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress

Imaizumi, K, Kanemoto, S, Saito, A, Ogata, M, Wanaka, A, Kondo, S, Murakami, T

J. Neurochem. 2006
15665855 OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes

Imaizumi, K, Tatsumi, K, Otori, K, Kanemoto, S, Iseki, K, Ogata, M, Wanaka, A, Kondo, S, Murakami, T

Nat. Cell Biol. 2005
Participants
Catalyst Activity

serine-type endopeptidase activity of Mbtps1 [Golgi membrane]

Orthologous Events
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