ATF6B (ATF6-beta) translocates from the endoplasmic reticulum to the Golgi

Stable Identifier
R-HSA-8874138
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Golgi membrane, endoplasmic reticulum membrane
ReviewStatus
5/5
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ATF6B (ATF6-beta) translocates from the endoplasmic reticulum to the Golgi
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In unstressed cells, ATF6B resides in the endoplasmic reticulum (ER) membrane due to its transmembrane domain (Haze et al. 2001). During ER stress, ATF6B traffics to the Golgi membrane where it is cleaved. As inferred from the homologous ATF6, ATF6B is likely complexed with HSPA5 (BiP, GRP78) in the ER of unstressed cells and is released from the complex during stress, exposing Golgi localization signals in ATF6B. Deletion of the C-terminal domain of ATF6B causes increased production of membrane proteins, possibly due to constitutive transit of the N-terminal domain to the nucleus (Choi et al. 2025).
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Inferred From
ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Homo sapiens)
Authored
May, B  (2016-05-15)
Reviewed
Kadambat Nair, S  (2025-09-16)
Created
May, B  (2016-05-21)
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