ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi

Stable Identifier
R-HSA-381186
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, Golgi membrane
ReviewStatus
5/5
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ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi
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The association between ATF6-alpha and BiP causes ATF6-alpha to be retained in the endoplasmic reticulum (ER). Once dissociated from BiP, the two Golgi Localization Sequences on ATF6-alpha are exposed and ATF6-alpha transits from the ER to the Golgi Apparatus.
Literature References
PubMed ID Title Journal Year
15657421 Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response

Shen, J, Snapp, EL, Lippincott-Schwartz, J, Prywes, R

Mol Cell Biol 2005
12110171 ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

Shen, J, Chen, X, Hendershot, L, Prywes, R

Dev Cell 2002
11821395 The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi

Chen, X, Shen, J, Prywes, R

J Biol Chem 2002
Participants
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Orthologous Events
CREB3L4 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)
ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Bos taurus)
ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Caenorhabditis elegans)
ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Canis familiaris)
ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Danio rerio)
ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Dictyostelium discoideum)
ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Drosophila melanogaster)
ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Gallus gallus)
ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Mus musculus)
ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Rattus norvegicus)
ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Sus scrofa)
ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Xenopus tropicalis)
CREB3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)
ATF6B (ATF6-beta) translocates from the endoplasmic reticulum to the Golgi (Homo sapiens)
Authored
May, B  (2009-06-02)
Reviewed
D'Eustachio, P  (2008-12-02)
Matthews, L  (2008-12-02)
Gillespie, ME  (2008-12-02)
Urano, F  (2010-04-30)
Created
May, B  (2008-11-19)
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