ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi

Stable Identifier
R-HSA-381186
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The association between ATF6-alpha and BiP causes ATF6-alpha to be retained in the endoplasmic reticulum (ER). Once dissociated from BiP, the two Golgi Localization Sequences on ATF6-alpha are exposed and ATF6-alpha transits from the ER to the Golgi Apparatus.

Literature References
PubMed ID Title Journal Year
12110171 ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

Shen, J, Chen, X, Hendershot, L, Prywes, R

Dev Cell 2002
15657421 Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response

Shen, J, Snapp, EL, Lippincott-Schwartz, J, Prywes, R

Mol Cell Biol 2005
11821395 The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi

Chen, X, Shen, J, Prywes, R

J Biol Chem 2002
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