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OTUD3 [cytosol]
Stable Identifier
R-HSA-8873955
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
OTU domain-containing protein 3 ecNumber3.4.19.12/ecNumber, OTUD3_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ovarian tumor domain proteases (Homo sapiens)
OTUD3 deubiquitinates PTEN (Homo sapiens)
OTUD3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN stability and activity (Homo sapiens)
USP13 and OTUD3 deubiquitinate PTEN (Homo sapiens)
USP13,OTUD3 [cytosol] (Homo sapiens)
OTUD3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5T2D3 OTUD3
Gene Names
OTUD3, KIAA0459
Chain
chain:1-398
Reference Genes
BioGPS Gene:23252 OTUD3
COSMIC (genes):OTUD3 OTUD3
CTD Gene:23252 OTUD3
dbSNP Gene:23252 OTUD3
ENSEMBL:ENSG00000169914 OTUD3
HGNC:29038 OTUD3
KEGG:hsa:23252 OTUD3
Monarch:23252 OTUD3
NCBI Gene:23252 OTUD3
OMIM:611758 OTUD3
UCSC:Q5T2D3 OTUD3
Reference Transcript
RefSeq:NM_015207.1 OTUD3
Other Identifiers
11723571_at
11723572_at
16660269
213216_PM_at
213216_at
2323827
2323828
2323829
2323831
2323832
2323833
2323834
2323835
2323837
2323838
2323839
2323840
23252
39621_at
7898602
A_24_P8575
A_24_P941188
GE494400
GE53199
GO:0003824
GO:0004843
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006508
GO:0008234
GO:0016579
GO:0016787
GO:0031669
GO:0035871
GO:0043226
GO:0044313
GO:0050821
GO:0051898
GO:0071108
GO:0140096
GO:1990167
HMNXSV003004820
HMNXSV003051221
Hs.28169.0.S1_3p_at
ILMN_1779280
PH_hs_0018187
PH_hs_0033655
TC01000253.hg
Participates
as a member of
USP13,OTUD3 [cytosol] (Homo sapiens)
Inferred To
OTUD3 [cytosol]
(Bos taurus)
OTUD3 [cytosol]
(Canis familiaris)
OTUD3 [cytosol]
(Dictyostelium discoideum)
OTUD3 [cytosol]
(Gallus gallus)
OTUD3 [cytosol]
(Sus scrofa)
duo-1 [cytosol]
(Caenorhabditis elegans)
otud3 [cytosol]
(Danio rerio)
otud3 [cytosol]
(Xenopus tropicalis)
Otud3 [cytosol]
(Mus musculus)
Otud3 [cytosol]
(Rattus norvegicus)
Cross References
ENSEMBL
ENSP00000364261
,
ENST00000375120
,
ENSG00000169914
OpenTargets
ENSG00000169914
IntEnz
3.4.19.12
GeneCards
OTUD3
HPA
ENSG00000169914-OTUD3
PRO
Q5T2D3
Pharos - Targets
Q5T2D3
PDB
4BOU
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y664 KPTN
1
KPTN [lysosomal membrane]
(R-HSA-9638238)
0.641
8
UniProt:P60484-1 PTEN
0.591
9
UniProt:Q969R8 ITFG2
1
ITFG2 [lysosomal membrane]
(R-HSA-9638231)
0.564
3
UniProt:Q9BPX1 HSD17B14
1
HSD17B14 [cytosol]
(R-HSA-6810587)
0.556
3
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