Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ITFG2 [lysosomal membrane]
Stable Identifier
R-HSA-9638231
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
fullName evidence="4"KICSTOR complex protein ITFG2, ITFG2_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Amino acids regulate mTORC1 (Homo sapiens)
BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
KICSTOR [lysosomal membrane] (Homo sapiens)
ITFG2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:BMT2 [lysosomal membrane] (Homo sapiens)
KICSTOR [lysosomal membrane] (Homo sapiens)
ITFG2 [lysosomal membrane] (Homo sapiens)
CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
KICSTOR [lysosomal membrane] (Homo sapiens)
ITFG2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
KICSTOR [lysosomal membrane] (Homo sapiens)
ITFG2 [lysosomal membrane] (Homo sapiens)
CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
KICSTOR [lysosomal membrane] (Homo sapiens)
ITFG2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
KICSTOR [lysosomal membrane] (Homo sapiens)
ITFG2 [lysosomal membrane] (Homo sapiens)
RRAGA,B hydrolyzes GTP (Homo sapiens)
KICSTOR:GATOR1:BMT2 [lysosomal membrane] (Homo sapiens)
KICSTOR [lysosomal membrane] (Homo sapiens)
ITFG2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
KICSTOR [lysosomal membrane] (Homo sapiens)
ITFG2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
KICSTOR [lysosomal membrane] (Homo sapiens)
ITFG2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
KICSTOR [lysosomal membrane] (Homo sapiens)
ITFG2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
KICSTOR [lysosomal membrane] (Homo sapiens)
ITFG2 [lysosomal membrane] (Homo sapiens)
SESN1,2 binds L-leucine and dissociates from GATOR2 (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
KICSTOR [lysosomal membrane] (Homo sapiens)
ITFG2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
KICSTOR [lysosomal membrane] (Homo sapiens)
ITFG2 [lysosomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q969R8 ITFG2
Gene Names
ITFG2
Chain
chain:1-447
Reference Genes
BioGPS Gene:55846 ITFG2
COSMIC (genes):ITFG2 ITFG2
CTD Gene:55846 ITFG2
dbSNP Gene:55846 ITFG2
ENSEMBL:ENSG00000111203 ITFG2
HGNC:30879 ITFG2
KEGG:hsa:55846 ITFG2
Monarch:55846 ITFG2
NCBI Gene:55846 ITFG2
OMIM:617421 ITFG2
UCSC:Q969R8 ITFG2
Reference Transcript
RefSeq:NM_018463.3 ITFG2
Other Identifiers
11742956_a_at
11745298_s_at
11755191_s_at
11759938_a_at
11760718_at
16746831
16746857
214148_PM_at
214148_at
220589_3p_s_at
220589_PM_s_at
220589_s_at
220590_PM_at
220590_at
226295_PM_at
226295_at
3401125
3401126
3401127
3401132
3401133
3401134
3401135
3401136
3401137
3401138
3401139
3401140
3401141
3401142
3401143
3401144
3401145
3401147
3401148
3401149
3401150
3401151
3401152
3401153
3401154
3401155
3401157
3401166
3401167
3401168
3401169
3401175
3401187
3401188
3401189
3401190
3401191
3401193
3401194
3401195
3401196
41323_at
41324_g_at
44522_at
55846
7953111
7953128
88618_at
A_23_P204417
A_24_P196038
GE87047
GE890699
GO:0002314
GO:0005515
GO:0005654
GO:0005764
GO:0005765
GO:0005794
GO:0005829
GO:0007229
GO:0016020
GO:0032006
GO:0034198
GO:0042149
GO:0140007
GO:1904262
HMNXSV003023585
HMNXSV003026232
HMNXSV003031914
Hs.239.3.A1_3p_at
Hs.29647.1.S1_3p_at
PH_hs_0026069
TC12000029.hg
TC12000030.hg
TC12000031.hg
TC12002178.hg
g8923927_3p_a_at
g8923927_3p_at
p28481
Participates
as a component of
KICSTOR [lysosomal membrane] (Homo sapiens)
Inferred To
itfg2 [lysosomal membrane]
(Danio rerio)
itfg2 [lysosomal membrane]
(Xenopus tropicalis)
Itfg2 [lysosomal membrane]
(Mus musculus)
Itfg2 [lysosomal membrane]
(Rattus norvegicus)
ITFG2 [lysosomal membrane]
(Bos taurus)
ITFG2 [lysosomal membrane]
(Canis familiaris)
ITFG2 [lysosomal membrane]
(Dictyostelium discoideum)
ITFG2 [lysosomal membrane]
(Gallus gallus)
ITFG2 [lysosomal membrane]
(Sus scrofa)
Cross References
RefSeq
NP_060933.3
ENSEMBL
ENSG00000111203
,
ENST00000644517
,
ENST00000228799
,
ENSP00000443329
,
ENSP00000496068
,
ENST00000540929
,
ENSP00000228799
OpenTargets
ENSG00000111203
GeneCards
ITFG2
HPA
ENSG00000111203-ITFG2
PRO
Q969R8
Pharos - Targets
Q969R8
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5T2D3 OTUD3
1
OTUD3 [cytosol]
(R-HSA-8873955)
0.564
3
UniProt:Q7KYR7 BTN2A1
1
BTN2A1 [plasma membrane]
(R-HSA-8851994)
0.527
2
© 2025
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text