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Calpain1,Calpain2:Ca2+:CAST [plasma membrane]
Stable Identifier
R-HSA-8868137
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
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Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
CAST binds Ca2+ bound calpain (Homo sapiens)
Calpain1,Calpain2:Ca2+:CAST [plasma membrane] (Homo sapiens)
Calpain cleaves p35 to p25 (Homo sapiens)
Calpain1,Calpain2:Ca2+:CAST [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
19020623
Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
Campbell, RL
,
Davies, PL
,
Hanna, RA
Nature
2008
7698360
Preference of calcium-dependent interactions between calmodulin-like domains of calpain and calpastatin subdomains
Mäki, M
,
Ma, H
,
Takano, E
,
Hatanaka, M
,
Yang, HQ
FEBS Lett.
1995
Participants
components
Calpain1, Calpain2:Ca2+ [plasma membrane]
(Homo sapiens)
CAST [cytosol]
(Homo sapiens)
Participates
as an output of
CAST binds Ca2+ bound calpain (Homo sapiens)
This entity regulates
Negatively
Calpain cleaves p35 to p25
(Homo sapiens)
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