CAST binds Ca2+ bound calpain

Stable Identifier
R-HSA-8868134
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The proteolytic activity of calpain complexes is inhibited by binding to calpastatin (CAST) (Takano et al. 1995). Based on detailed structural studies of recombinant rat proteins, CAST associates with calcium-bound calpain heterodimers and occupies both sides of the calpain active site cleft (Hanna et al. 2008). CAST levels are reduced in Alzheimer disease (Sato et al. 2011).

Literature References
PubMed ID Title Journal Year
7698360 Preference of calcium-dependent interactions between calmodulin-like domains of calpain and calpastatin subdomains

Takano, E, Ma, H, Yang, HQ, Mäki, M, Hatanaka, M

FEBS Lett. 1995
Participants
Participant Of
Authored
Created