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CAST binds Ca2+ bound calpain
Stable Identifier
R-HSA-8868134
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
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Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
CAST binds Ca2+ bound calpain (Homo sapiens)
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The proteolytic activity of calpain complexes is inhibited by binding to calpastatin (CAST) (Takano et al. 1995). Based on detailed structural studies of recombinant rat proteins, CAST associates with calcium-bound calpain heterodimers and occupies both sides of the calpain active site cleft (Hanna et al. 2008). CAST levels are reduced in Alzheimer disease (Sato et al. 2011).
Literature References
PubMed ID
Title
Journal
Year
7698360
Preference of calcium-dependent interactions between calmodulin-like domains of calpain and calpastatin subdomains
Mäki, M
,
Ma, H
,
Takano, E
,
Hatanaka, M
,
Yang, HQ
FEBS Lett.
1995
Participants
Input
Calpain1, Calpain2:Ca2+ [plasma membrane]
(Homo sapiens)
CAST [cytosol]
(Homo sapiens)
Output
Calpain1,Calpain2:Ca2+:CAST [plasma membrane]
(Homo sapiens)
Participates
as an event of
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
Authored
Shah, K (2016-02-23)
Created
Orlic-Milacic, M (2016-04-19)
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