TFAP2 (AP-2) family regulates transcription of other transcription factors

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R-HSA-8866906
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Pathway
Species
Homo sapiens
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TFAP2 (AP-2) family regulates transcription of other transcription factors
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Homodimers and possibly heterodimers of TFAP2A and TFAP2C, in complex with CITED2, stimulate transcription of the PITX2 gene, involved in left-right patterning and heart development (Bamforth et al. 2004, Li et al. 2012).

Literature References
PubMed ID Title Journal Year
15475956 Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway

Anderson, RH, Bhattacharya, S, Farthing, CR, Broadbent, C, Neubauer, S, Bragança, J, Clarke, K, Bamforth, SD, Schneider, JE, Michell, AC, Norris, D, Brown, NA

Nat. Genet. 2004
22735262 CITED2 mutation links congenital heart defects to dysregulation of the cardiac gene VEGF and PITX2C expression

Pan, H, Guan, L, Li, Q, Su, D, Ma, X

Biochem. Biophys. Res. Commun. 2012
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positive regulation of transcription by RNA polymerase II (0045944)
Authored
Orlic-Milacic, M  (2016-03-14)
Reviewed
Zarelli, VE  (2016-05-04)
Bogachek, MV  (2016-05-17)
Dawid, IB  (2016-05-04)
Weigel, RJ  (2016-05-17)
Created
Orlic-Milacic, M  (2016-04-04)
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