TFAP2 (AP-2) family regulates transcription of other transcription factors

Stable Identifier
R-HSA-8866906
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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TFAP2 (AP-2) family regulates transcription of other transcription factors
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Homodimers and possibly heterodimers of TFAP2A and TFAP2C, in complex with CITED2, stimulate transcription of the PITX2 gene, involved in left-right patterning and heart development (Bamforth et al. 2004, Li et al. 2012).
Literature References
PubMed ID Title Journal Year
15475956 Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway

Bamforth, SD, Bragança, J, Farthing, CR, Schneider, JE, Broadbent, C, Michell, AC, Clarke, K, Neubauer, S, Norris, D, Brown, NA, Anderson, RH, Bhattacharya, S

Nat. Genet. 2004
22735262 CITED2 mutation links congenital heart defects to dysregulation of the cardiac gene VEGF and PITX2C expression

Li, Q, Pan, H, Guan, L, Su, D, Ma, X

Biochem. Biophys. Res. Commun. 2012
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Go Biological Process
positive regulation of transcription by RNA polymerase II (0045944)
Authored
Orlic-Milacic, M  (2016-03-14)
Reviewed
Dawid, IB  (2016-05-04)
Zarelli, VE  (2016-05-04)
Bogachek, MV  (2016-05-17)
Weigel, RJ  (2016-05-17)
Created
Orlic-Milacic, M  (2016-04-04)
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