PITX2 gene expression is stimulated by TFAP2A,TFAP2C homodimers:CITED2

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R-HSA-8864729
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Reaction [omitted]
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Homo sapiens
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The PITX2 gene encodes a homeobox transcription factor involved in left-right patterning and heart development. The PITX2 gene expression is stimulated by binding of the complex of CITED2 and TFAP2A or TFAP2C homodimers to the AP-2 response elements in the PITX2 promoter (Bamforth et al. 2004, Li et al. 2012).

Literature References
PubMed ID Title Journal Year
22735262 CITED2 mutation links congenital heart defects to dysregulation of the cardiac gene VEGF and PITX2C expression

Li, Q, Pan, H, Guan, L, Su, D, Ma, X

Biochem. Biophys. Res. Commun. 2012
15475956 Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway

Bamforth, SD, Bragan├ža, J, Farthing, CR, Schneider, JE, Broadbent, C, Michell, AC, Clarke, K, Neubauer, S, Norris, D, Brown, NA, Anderson, RH, Bhattacharya, S

Nat. Genet. 2004
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