PITX2 gene expression is stimulated by TFAP2A,TFAP2C homodimers:CITED2

Stable Identifier
Reaction [omitted]
Homo sapiens
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The PITX2 gene encodes a homeobox transcription factor involved in left-right patterning and heart development. The PITX2 gene expression is stimulated by binding of the complex of CITED2 and TFAP2A or TFAP2C homodimers to the AP-2 response elements in the PITX2 promoter (Bamforth et al. 2004, Li et al. 2012).

Literature References
PubMed ID Title Journal Year
15475956 Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway

Anderson, RH, Bhattacharya, S, Farthing, CR, Broadbent, C, Neubauer, S, Bragan├ža, J, Clarke, K, Bamforth, SD, Schneider, JE, Michell, AC, Norris, D, Brown, NA

Nat. Genet. 2004
22735262 CITED2 mutation links congenital heart defects to dysregulation of the cardiac gene VEGF and PITX2C expression

Pan, H, Guan, L, Li, Q, Su, D, Ma, X

Biochem. Biophys. Res. Commun. 2012
This event is regulated