TFAP2A,TFAP2C homodimers:CITED2 binds PITX2 gene promoter

Stable Identifier
R-HSA-8864718
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TFAP2A,TFAP2C homodimers:CITED2 binds PITX2 gene promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Homodimers of AP-2 transcription factor family members TFAP2A (AP-2 alpha) and TFAP2C (AP-2 gamma), in complex with CITED2, bind to the evolutionarily conserved AP-2 response elements in the promoter of the PITX2 gene (Bamforth et al. 2004, Li et al. 2012).
Literature References
PubMed ID Title Journal Year
15475956 Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway

Anderson, RH, Bhattacharya, S, Farthing, CR, Broadbent, C, Neubauer, S, Bragança, J, Clarke, K, Bamforth, SD, Schneider, JE, Michell, AC, Norris, D, Brown, NA

Nat. Genet. 2004
22735262 CITED2 mutation links congenital heart defects to dysregulation of the cardiac gene VEGF and PITX2C expression

Pan, H, Guan, L, Li, Q, Su, D, Ma, X

Biochem. Biophys. Res. Commun. 2012
Participants
Input
Output
Participates
as an event of
Authored
Orlic-Milacic, M  (2016-03-14)
Reviewed
Zarelli, VE  (2016-05-04)
Bogachek, MV  (2016-05-17)
Dawid, IB  (2016-05-04)
Weigel, RJ  (2016-05-17)
Created
Orlic-Milacic, M  (2016-03-16)
Cite Us!