TFAP2A,TFAP2C homodimers:CITED2 binds PITX2 gene promoter

Stable Identifier
R-HSA-8864718
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Homodimers of AP-2 transcription factor family members TFAP2A (AP-2 alpha) and TFAP2C (AP-2 gamma), in complex with CITED2, bind to the evolutionarily conserved AP-2 response elements in the promoter of the PITX2 gene (Bamforth et al. 2004, Li et al. 2012).

Literature References
PubMed ID Title Journal Year
22735262 CITED2 mutation links congenital heart defects to dysregulation of the cardiac gene VEGF and PITX2C expression

Li, Q, Pan, H, Guan, L, Su, D, Ma, X

Biochem. Biophys. Res. Commun. 2012
15475956 Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway

Bamforth, SD, Bragan├ža, J, Farthing, CR, Schneider, JE, Broadbent, C, Michell, AC, Clarke, K, Neubauer, S, Norris, D, Brown, NA, Anderson, RH, Bhattacharya, S

Nat. Genet. 2004
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