TFAP2A homodimer binds CDKN1A (p21) gene

Stable Identifier
Reaction [binding]
Homo sapiens
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TFAP2A (AP-2 alpha) transcription factor binds two AP-2 response elements in the promoter of the CDKN1A (p21) gene, the proximal site being TP53 (p53) independent, while the distal site is in the vicinity of the p53 response element (Zeng et al. 1997, Williams et al. 2009, Scibetta et al. 2010).

Literature References
PubMed ID Title Journal Year
19798054 AP-2gamma promotes proliferation in breast tumour cells by direct repression of the CDKN1A gene

Williams, CM, Scibetta, AG, Friedrich, JK, Canosa, M, Berlato, C, Moss, CH, Hurst, HC

EMBO J. 2009
8988173 AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression

Zeng, YX, Somasundaram, K, el-Deiry, WS

Nat. Genet. 1997
21084835 Dual association by TFAP2A during activation of the p21cip/CDKN1A promoter

Scibetta, AG, Wong, PP, Chan, KV, Canosa, M, Hurst, HC

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