Reactome | TFAP2 (AP-2) family regulates transcription of cell cycle factors

TFAP2 (AP-2) family regulates transcription of cell cycle factors

Stable Identifier

R-HSA-8866911

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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TFAP2 (AP-2) family regulates transcription of cell cycle factors

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TFAP2A and TFAP2C play opposing roles in transcriptional regulation of the CDKN1A (p21) gene locus. While TFAP2A stimulates transcription of the CDKN1A cyclin-dependent kinase inhibitor (Zeng et al. 1997, Williams et al. 2009, Scibetta et al. 2010), TFAP2C, in cooperation with MYC and histone demethylase KDM5B, represses CDKN1A transcription (Williams et al. 2009, Scibetta et al. 2010, Wong et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
8988173	AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression Zeng, YX, Somasundaram, K, el-Deiry, WS	Nat. Genet.	1997
22371483	Histone demethylase KDM5B collaborates with TFAP2C and Myc to repress the cell cycle inhibitor p21(cip) (CDKN1A) Wong, PP, Miranda, F, Chan, KV, Berlato, C, Hurst, HC, Scibetta, AG	Mol. Cell. Biol.	2012
19798054	AP-2gamma promotes proliferation in breast tumour cells by direct repression of the CDKN1A gene Williams, CM, Scibetta, AG, Friedrich, JK, Canosa, M, Berlato, C, Moss, CH, Hurst, HC	EMBO J.	2009
21084835	Dual association by TFAP2A during activation of the p21cip/CDKN1A promoter Scibetta, AG, Wong, PP, Chan, KV, Canosa, M, Hurst, HC	Cell Cycle	2010