VEGFA gene expression is inhibited by the TFAP2A homodimer

Stable Identifier
R-HSA-8864936
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region, nucleoplasm
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VEGFA gene expression is inhibited by the TFAP2A homodimer
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Binding of TFAP2A (AP-2 alpha) dimer to AP-2 response elements in the VEGFA gene promoter results in repression of VEGFA expression (Ruiz et al. 2004). CITED2, a transcription co-factor of TFAP2A, also represses VEGFA transcription, but the mechanism has not been established (Li et al. 2012).

Literature References
PubMed ID Title Journal Year
14744778 Activator protein 2alpha inhibits tumorigenicity and represses vascular endothelial growth factor transcription in prostate cancer cells

Ruiz, M, Pettaway, C, Song, R, Stoeltzing, O, Ellis, L, Bar-Eli, M

Cancer Res. 2004
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
TFAP2A homodimer:VEGFA Gene [nucleoplasm] (Homo sapiens)
Active Unit
TFAP2A homodimer [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-03-14)
Reviewed
Dawid, IB  (2016-05-04)
Zarelli, VE  (2016-05-04)
Bogachek, MV  (2016-05-17)
Weigel, RJ  (2016-05-17)
Created
Orlic-Milacic, M  (2016-03-16)
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