Reactome | TFAP2 (AP-2) family regulates transcription of growth factors and their receptors

TFAP2 (AP-2) family regulates transcription of growth factors and their receptors

Stable Identifier

R-HSA-8866910

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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TFAP2 (AP-2) family regulates transcription of growth factors and their receptors

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TFAP2A and TFAP2C directly stimulate transcription of the estrogen receptor ESR1 gene (McPherson and Weigel 1999). TFAP2A expression correlates with ESR1 expression in breast cancer, and TFAP2C is frequently overexpressed in estrogen-positive breast cancer and endometrial cancer (deConinck et al. 1995, Turner et al. 1998). TFAP2A, TFAP2C, as well as TFAP2B can directly stimulate the expression of ERBB2, another important breast cancer gene (Bosher et al. 1996). Association of TFAP2A with the YY1 transcription factor significantly increases the ERBB2 transcription rate (Begon et al. 2005). In addition to ERBB2, the expression of another receptor tyrosine kinase, KIT, is also stimulated by TFAP2A and TFAP2B (Huang et al. 1998), while the expression of the VEGF receptor tyrosine kinase ligand VEGFA is repressed by TFAP2A (Ruiz et al. 2004, Li et al. 2012). TFAP2A stimulates transcription of the transforming growth factor alpha (TGFA) gene (Wang et al. 1997). TFAP2C regulates EGFR expression in luminal breast cancer (De Andrade et al. 2016). In placenta, TFAP2A and TFAP2C directly stimulate transcription of both subunits of the human chorionic gonadotropin, CGA and CGB (Johnson et al. 1997, LiCalsi et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
9162057	Transcription factor AP-2 controls transcription of the human transforming growth factor-alpha gene Wang, D, Shin, TH, Kudlow, JE	J. Biol. Chem.	1997
10648798	AP-2 family members regulate basal and cAMP-induced expression of human chorionic gonadotropin LiCalsi, C, Fischer, W, Buescher, M, Mellon, PL, Christophe, S, Steger, DJ	Nucleic Acids Res.	2000
9850080	Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways Carter, D, Glazer, PM, Williams, T, Gumbs, AA, Zhang, J, Haffty, BG, Hurst, HC, Maher, MG, Turner, BC, Kaplan, L	Cancer Res.	1998
22735262	CITED2 mutation links congenital heart defects to dysregulation of the cardiac gene VEGF and PITX2C expression Pan, H, Guan, L, Li, Q, Su, D, Ma, X	Biochem. Biophys. Res. Commun.	2012
14744778	Activator protein 2alpha inhibits tumorigenicity and represses vascular endothelial growth factor transcription in prostate cancer cells Bar-Eli, M, Song, R, Ruiz, M, Pettaway, C, Stoeltzing, O, Ellis, L	Cancer Res.	2004
26832794	EGFR Is Regulated by TFAP2C in Luminal Breast Cancer and Is a Target for Vandetanib Lorenzen, AW, Spanheimer, PM, Weigel, RJ, Van Dorin, SE, Park, JM, Kulak, MV, Wu, VT, De Andrade, JP, Gu, VW, Woodfield, GW	Mol. Cancer Ther.	2016
7891714	Transcriptional regulation of estrogen receptor in breast carcinomas deConinck, EC, Weigel, RJ, McPherson, LA	Mol. Cell. Biol.	1995
8895516	A family of AP-2 proteins regulates c-erbB-2 expression in mammary carcinoma Williams, T, Totty, NF, Bosher, JM, Hsuan, JJ, Hurst, HC	Oncogene	1996
9687504	Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis Huang, S, Bar-Eli, M, Luca, M, Jean, D, Tainsky, MA	EMBO J.	1998
10497269	AP2alpha and AP2gamma: a comparison of binding site specificity and trans-activation of the estrogen receptor promoter and single site promoter constructs Weigel, RJ, McPherson, LA	Nucleic Acids Res.	1999
9182571	Regulation of the human chorionic gonadotropin alpha- and beta-subunit promoters by AP-2 Johnson, W, Albanese, C, Jameson, JL, Pestell, RG, Williams, T, Handwerger, S	J. Biol. Chem.	1997
15870067	Yin Yang 1 cooperates with activator protein 2 to stimulate ERBB2 gene expression in mammary cancer cells Jackers, P, Vernimmen, D, Begon, DY, Winkler, R, Delacroix, L	J. Biol. Chem.	2005