Reactome | Fem1c [cytosol]

Fem1c [cytosol]

Stable Identifier

R-MMU-8863167

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

FEM1C, Q8CEF1

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Neddylation (Mus musculus)
    - AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        Fem1c [cytosol] (Mus musculus)
      - NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        Fem1c [cytosol] (Mus musculus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        Fem1c [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        Fem1c [cytosol] (Mus musculus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        Fem1c [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        Fem1c [cytosol] (Mus musculus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        Fem1c [cytosol] (Mus musculus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        Fem1c [cytosol] (Mus musculus)
    - NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Mus musculus)
      - CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        Fem1c [cytosol] (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        Fem1c [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8CEF1

Gene Names

Fem1c

Reference Genes

BioGPS Gene:240263 Fem1c

ENSEMBL:ENSMUSG00000033319

KEGG:mmu:240263 Fem1c

Monarch:240263 Fem1c

NCBI Gene:240263 Fem1c

UCSC:Q8CEF1 Fem1c

Reference Transcript

RefSeq:NM_173423.4 Fem1c

Other Identifiers

10458808

111088_at

113282_at

1428890_at

1438075_at

163538_at

17354263

240263

4539238

4631299

4782798

4881117

5066264

5122534

5314845

5491704

5533981

5535672

5595661

A_51_P300266

A_51_P359549

A_52_P644020

A_52_P659917

GE138646

GE39618

GO:0000151

GO:0005515

GO:0005654

GO:0005829

GO:0006511

GO:0016567

GO:0030163

GO:0031462

GO:0043161

GO:0060090

GO:0140627

GO:1990756

ILMN_2614663

ILMN_2641669

ILMN_2724409

mMC013024

mMC013418

mMC022884

Participates

as a member of

CUL2-box protein [cytosol] (Mus musculus)

Inferred From

FEM1C [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSMUSP00000038816, ENSMUSG00000033319, ENSMUST00000036226

PRO

Q8CEF1

MGI

2444737