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SKP1:CUL1:RBX1:FBXL7 [cytosol]
Stable Identifier
R-HSA-8854030
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
SCF-FBXL7
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Homo sapiens)
Formation of the SCF-FBXL7 complex (Homo sapiens)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Homo sapiens)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Homo sapiens)
SCF-FBXL7:PolyUb-AURKA [cytosol] (Homo sapiens)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Homo sapiens)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Homo sapiens)
SCF-FBXL7 ubiquitinates AURKA (Homo sapiens)
SCF-FBXL7:AURKA [cytosol] (Homo sapiens)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Homo sapiens)
SCF-FBXL7:PolyUb-AURKA [cytosol] (Homo sapiens)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Homo sapiens)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Homo sapiens)
SCF:FBXL7 binds AURKA (Homo sapiens)
SCF-FBXL7:AURKA [cytosol] (Homo sapiens)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Homo sapiens)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
22306998
Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest
Glasser, JR
,
Chen, BB
,
Coon, TA
,
Mallampalli, RK
Cell Cycle
2012
Participants
components
CUL1 [cytosol]
(Homo sapiens)
FBXL7 [cytosol]
(Homo sapiens)
RBX1 [cytosol]
(Homo sapiens)
SKP1 [cytosol]
(Homo sapiens)
Participates
as an output of
Formation of the SCF-FBXL7 complex (Homo sapiens)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Homo sapiens)
as an input of
SCF:FBXL7 binds AURKA (Homo sapiens)
as a component of
SCF-FBXL7:AURKA [cytosol] (Homo sapiens)
SCF-FBXL7:PolyUb-AURKA [cytosol] (Homo sapiens)
Inferred To
SKP1:CUL1:RBX1:FBXL7 [cytosol]
(Bos taurus)
SKP1:CUL1:RBX1:FBXL7 [cytosol]
(Caenorhabditis elegans)
SKP1:CUL1:RBX1:FBXL7 [cytosol]
(Canis familiaris)
SKP1:CUL1:RBX1:FBXL7 [cytosol]
(Danio rerio)
SKP1:CUL1:RBX1:FBXL7 [cytosol]
(Dictyostelium discoideum)
SKP1:CUL1:RBX1:FBXL7 [cytosol]
(Drosophila melanogaster)
SKP1:CUL1:RBX1:FBXL7 [cytosol]
(Gallus gallus)
SKP1:CUL1:RBX1:FBXL7 [cytosol]
(Mus musculus)
SKP1:CUL1:RBX1:FBXL7 [cytosol]
(Plasmodium falciparum)
SKP1:CUL1:RBX1:FBXL7 [cytosol]
(Rattus norvegicus)
SKP1:CUL1:RBX1:FBXL7 [cytosol]
(Saccharomyces cerevisiae)
SKP1:CUL1:RBX1:FBXL7 [cytosol]
(Schizosaccharomyces pombe)
SKP1:CUL1:RBX1:FBXL7 [cytosol]
(Sus scrofa)
SKP1:CUL1:RBX1:FBXL7 [cytosol]
(Xenopus tropicalis)
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