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TPX2 [cytosol]
Stable Identifier
R-HSA-8853407
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Targeting protein for Xklp2
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
AURKA Activation by TPX2 (Homo sapiens)
TPX2 binds AURKA at centrosomes (Homo sapiens)
Centrosome:AURKA:TPX2:HMMR [cytosol] (Homo sapiens)
TPX2 [cytosol] (Homo sapiens)
TPX2 [cytosol] (Homo sapiens)
TPX2 promotes AURKA autophosphorylation (Homo sapiens)
Centrosome:AURKA:TPX2:HMMR [cytosol] (Homo sapiens)
TPX2 [cytosol] (Homo sapiens)
Centrosome:p-T288-AURKA:TPX2:HMMR [cytosol] (Homo sapiens)
TPX2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9ULW0 TPX2
Gene Names
TPX2, C20orf1, C20orf2, DIL2, HCA519
Chain
chain:1-747
Reference Genes
BioGPS Gene:22974 TPX2
COSMIC (genes):TPX2 TPX2
CTD Gene:22974 TPX2
dbSNP Gene:22974 TPX2
ENSEMBL:ENSG00000088325 TPX2
HGNC:1249 TPX2
KEGG Gene (Homo sapiens):22974 TPX2
Monarch:22974 TPX2
NCBI Gene:22974 TPX2
OMIM:605917 TPX2
UCSC:Q9ULW0 TPX2
Reference Transcript
RefSeq:XM_011528697.2 TPX2
RefSeq:NM_012112.4 TPX2
RefSeq:XM_011528699.2 TPX2
Other Identifiers
0003390500
11750598_s_at
16912379
210052_s_at
22974
3385724
3881447
3881448
3881451
3881454
3881455
3881457
3881458
3881459
3881462
3881463
3881464
3881467
3881468
3881470
3881472
3881476
3881477
3881478
3881479
3881482
3881483
3881487
3881488
3881489
3881490
3881491
3881492
3881493
39109_at
45574_g_at
8061579
A_23_P68610
GE53669
GO:0000278
GO:0000922
GO:0003674
GO:0005515
GO:0005575
GO:0005576
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005819
GO:0005829
GO:0005856
GO:0005874
GO:0006464
GO:0006915
GO:0007010
GO:0007020
GO:0007026
GO:0007049
GO:0007165
GO:0008150
GO:0008219
GO:0010389
GO:0015630
GO:0019899
GO:0019901
GO:0022607
GO:0032147
GO:0043203
GO:0043226
GO:0045171
GO:0051301
GO:0060236
GO:0061676
GO:0065003
GO:0072686
GO:0090307
GO:0140014
GO:1901796
ILMN_1792494
ILMN_1796949
PH_hs_0000972
TC20000198.hg
g6073830_3p_a_at
Participant Of
input
TPX2 binds AURKA at centrosomes
hasComponent
Centrosome:AURKA:TPX2:HMMR [cytosol]
Centrosome:p-T288-AURKA:TPX2:HMMR [cytosol]
Other forms of this molecule
TPX2 [nucleoplasm]
Inferred To
tpx2 [cytosol] (Danio rerio)
tpx2 [cytosol] (Xenopus tropicalis)
Tpx2 [cytosol] (Mus musculus)
Tpx2 [cytosol] (Rattus norvegicus)
TPX2 [cytosol] (Canis familiaris)
TPX2 [cytosol] (Gallus gallus)
TPX2 [cytosol] (Sus scrofa)
Cross References
RefSeq
XP_011526999.1
,
XP_011527001.1
,
NP_036244.2
Target Pathogen
5b354852be737e166372eae6
OpenTargets
ENSG00000088325
HPA
ENSG00000088325-TPX2
GeneCards
Q9ULW0
Ensembl
ENST00000300403
,
ENSG00000088325
,
ENST00000340513
,
ENSP00000300403
,
ENSP00000341145
PRO
Q9ULW0
PDB
3E5A
,
5LXM
,
1OL5
,
3HA6
,
4C3P
,
6BJC
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14965 AURKA
6
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
AURKA [nucleoplasm]
(R-HSA-4655443)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [cytosol]
(R-HSA-2574832)
0.85
8
UniProt:Q08379 GOLGA2
3
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.718
6
UniProt:Q8TDX7 NEK7
2
NEK7 [cytosol]
(R-HSA-2530599)
p-S195-NEK7 [cytosol]
(R-HSA-2984246)
0.556
3
UniProt:P27797 CALR
6
CALR [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-985502)
CALR [endoplasmic reticulum lumen]
(R-HSA-195905)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863866)
CALR [phagocytic vesicle membrane]
(R-HSA-1236879)
CALR [extracellular region]
(R-HSA-2197641)
CALR [endocytic vesicle lumen]
(R-HSA-2239448)
0.556
3
UniProt:P36957 DLST
2
Lipo-K110-DLST [mitochondrial matrix]
(R-HSA-69993)
DLST [mitochondrial matrix]
(R-HSA-6792574)
0.556
3
UniProt:P12830 CDH1
10
CDH1(751-882) [plasma membrane]
(R-HSA-3827962)
CDH1(732-882) [plasma membrane]
(R-HSA-3827997)
CDH1(155-750) [plasma membrane]
(R-HSA-3828000)
CDH1(155-700) [plasma membrane]
(R-HSA-2534244)
CDH1(701-882) [extracellular region]
(R-HSA-2534158)
Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8877002)
p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8876938)
CDH1(155-750) [plasma membrane]
(R-HSA-202940)
CDH1(751-882) [plasma membrane]
(R-HSA-202929)
CDH1(155-882) [plasma membrane]
(R-HSA-198003)
0.556
3
UniProt:Q15078 CDK5R1
4
CDK5R1(99-307) [nucleoplasm]
(R-HSA-6805262)
MyrG-CDK5R1(2-307) [plasma membrane]
(R-HSA-421083)
CDK5R1(99-307) [cytosol]
(R-HSA-8863415)
MyrG-CDK5R1(2-98) [plasma membrane]
(R-HSA-8863400)
0.556
3
UniProt:P38398 BRCA1
27
SUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
SUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
BRCA1 C64R [nucleoplasm]
(R-HSA-9700907)
BRCA1 C61G [nucleoplasm]
(R-HSA-9700890)
BRCA1 C39Y [nucleoplasm]
(R-HSA-9700938)
BRCA1 H41R [nucleoplasm]
(R-HSA-9700921)
BRCA1 C24R [nucleoplasm]
(R-HSA-9663198)
BRCA1 H41A [nucleoplasm]
(R-HSA-9700927)
BRCA1 M18T [nucleoplasm]
(R-HSA-9700911)
BRCA1 C47G [nucleoplasm]
(R-HSA-9700941)
BRCA1 C64G [nucleoplasm]
(R-HSA-9700899)
BRCA1 C44F [nucleoplasm]
(R-HSA-9700944)
BRCA1 T37R [nucleoplasm]
(R-HSA-9700934)
BRCA1 C27A [nucleoplasm]
(R-HSA-9700916)
BRCA1 H41Q [nucleoplasm]
(R-HSA-9700923)
BRCA1 Q12Tfs*5 [nucleoplasm]
(R-HSA-9700953)
BRCA1 E23Afs*18 [nucleoplasm]
(R-HSA-9700959)
BRCA1 C61Y [nucleoplasm]
(R-HSA-9700894)
BRCA1 C24F [nucleoplasm]
(R-HSA-9663206)
BRCA1 E23Rfs*18 [nucleoplasm]
(R-HSA-9700960)
BRCA1 E23Vfs*17 [nucleoplasm]
(R-HSA-9700967)
p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-5683800)
K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-9707298)
BRCA1 [nucleoplasm]
(R-HSA-50949)
K6PolyUb-BRCA1 [nucleoplasm]
(R-HSA-9701022)
K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-9707290)
p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-75234)
0.527
4
UniProt:O75330 HMMR
2
HMMR [cytosol]
(R-HSA-8861624)
HMMR [plasma membrane]
(R-HSA-2160885)
0.499
5
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