Reactome | TPX2 [nucleoplasm]

TPX2 [nucleoplasm]

Stable Identifier

R-HSA-2564700

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Targeting protein for Xklp2, DIL2, HCA519, C20orf1, C20orf2

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        AURKA phosphorylates TP53 (Homo sapiens)
        
        p-T288-AURKA:TPX2 [nucleoplasm] (Homo sapiens)
        
        TPX2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9ULW0 TPX2

Gene Names

TPX2, C20orf1, C20orf2, DIL2, HCA519

Chain

chain:1-747

Reference Genes

BioGPS Gene:22974 TPX2

COSMIC (genes):TPX2 TPX2

CTD Gene:22974 TPX2

dbSNP Gene:22974 TPX2

ENSEMBL:ENSG00000088325.16 TPX2

HGNC:1249 TPX2

KEGG Gene (Homo sapiens):22974 TPX2

Monarch:22974 TPX2

NCBI Gene:22974 TPX2

OMIM:605917 TPX2

UCSC:Q9ULW0 TPX2

Reference Transcript

Other Identifiers

0003390500

11750598_s_at

16912379

210052_PM_s_at

210052_s_at

22974

3385724

3881447

3881448

3881451

3881454

3881455

3881457

3881458

3881459

3881462

3881463

3881464

3881467

3881468

3881470

3881472

3881476

3881477

3881478

3881479

3881482

3881483

3881487

3881488

3881489

3881490

3881491

3881492

3881493

39109_at

45574_g_at

8061579

A_23_P68610

GE53669

GO:0000278

GO:0000922

GO:0005515

GO:0005576

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005819

GO:0005829

GO:0005856

GO:0005874

GO:0005880

GO:0006915

GO:0007010

GO:0007020

GO:0007026

GO:0007049

GO:0008017

GO:0008092

GO:0012501

GO:0015630

GO:0019901

GO:0030295

GO:0032147

GO:0036211

GO:0043203

GO:0043226

GO:0045171

GO:0051301

GO:0060236

GO:0061676

GO:0065003

GO:0072686

GO:0090307

GO:0098772

GO:0140014

HMNXSV003031020

ILMN_1792494

ILMN_1796949

PH_hs_0000972

TC20000198.hg

g6073830_3p_a_at

Participates

as a component of

p-T288-AURKA:TPX2 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

TPX2 [cytosol]

Inferred To

TPX2 [nucleoplasm] (Bos taurus)

TPX2 [nucleoplasm] (Canis familiaris)

TPX2 [nucleoplasm] (Danio rerio)

TPX2 [nucleoplasm] (Sus scrofa)

Tpx2 [nucleoplasm] (Mus musculus)

Tpx2 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_011527001.1, NP_036244.2, XP_011526999.1

OpenTargets

ENSG00000088325

GeneCards

Q9ULW0

HPA

ENSG00000088325-TPX2

Ensembl

ENST00000300403, ENSG00000088325, ENSP00000300403, ENSP00000341145, ENST00000340513

PRO

Q9ULW0

Pharos - Targets

Q9ULW0

PDB

6VPJ, 6VPI, 6XKA, 6VPM, 1OL5, 6VPH, 3E5A, 6BJC, 5LXM, 6VPL, 4C3P, 6VPG, 3HA6

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14965 AURKA	6	SUMO1-K258-AURKA [cytosol] (R-HSA-4655367) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) AURKA [nucleoplasm] (R-HSA-4655443) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [cytosol] (R-HSA-2574832)	0.85	8
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.611	4
UniProt:Q8TDX7 NEK7	2	NEK7 [cytosol] (R-HSA-2530599) p-S195-NEK7 [cytosol] (R-HSA-2984246)	0.556	3
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448)	0.556	3
UniProt:P36957 DLST	2	DLST [mitochondrial matrix] (R-HSA-6792574) Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993)	0.556	3
UniProt:P12830 CDH1	8	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.556	3
UniProt:Q15078 CDK5R1	4	MyrG-CDK5R1(2-307) [plasma membrane] (R-HSA-421083) CDK5R1(99-307) [nucleoplasm] (R-HSA-6805262) CDK5R1(99-307) [cytosol] (R-HSA-8863415) MyrG-CDK5R1(2-98) [plasma membrane] (R-HSA-8863400)	0.556	3
UniProt:O75330 HMMR	2	HMMR [plasma membrane] (R-HSA-2160885) HMMR [cytosol] (R-HSA-8861624)	0.499	5
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.483	4

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