GPR183 binds 7alpha,25-dihydroxycholesterol

Stable Identifier
Homo sapiens
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GPR183 (Epstein-Barr virus-induced gene 2, EBI2) is a G protein-coupled receptor that is expressed in peripheral blood mononuclear cells and the CNS. It is activated by the oxysterol 7-alpha-25-dihydroxycholesterol (7A25HC) (Hannedouche et al. 2011). EBI2 is coupled exclusively to Gi (Rosenkilde et al. 2006).

Literature References
PubMed ID Title Journal Year
21796212 Oxysterols direct immune cell migration via EBI2

Karuna, R, Noël, S, Koo, DI, Baumgarten, BU, Sailer, AW, Li, W, Nguyen, D, Miault, C, Roggo, S, Kelly, LM, Pereira, JP, Knochenmuss, R, Chen, YA, Katopodis, A, Gessier, F, Cyster, JG, Peters, EC, Hannedouche, S, Shen, W, Falchetto, R, Laurent, S, Cho, CY, Yi, T, Schultz, PG, Seuwen, K, Spanka, C, Detheux, M, Guerini, D, Schmedt, C, Preuss, I, Suply, T, Christen, I, Vanek, M, Wen, B, Roy, MO, Zhang, J

Nature 2011
16540462 Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity

Benned-Jensen, T, Schwartz, TW, Larsen, JK, Lüttichau, HR, Christensen, JP, Andersen, H, Kledal, TN, Holst, PJ, Rosenkilde, MM

J. Biol. Chem. 2006
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