PTK6 Down-Regulation

Stable Identifier
R-HSA-8849472
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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PTK6 Down-Regulation
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The kinase activity of PTK6 is negatively regulated by both PTPN1 phosphatase (Fan et al. 2013), which dephosphorylates tyrosine Y342 of PTK6, and SRMS kinase (Fan et al. 2015), which phosphorylates PTK6 on tyrosine residue Y447.

Literature References
PubMed ID Title Journal Year
25897081 Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase

Fan, G, Yang, M, Aleem, S, Miller, WT, Tonks, NK

J. Biol. Chem. 2015
23814047 Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells

Fan, G, Tonks, NK, Lin, G, Lucito, R

J. Biol. Chem. 2013
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
negative regulation of signal transduction (0009968)
Orthologous Events
PTK6 Down-Regulation (Bos taurus)
PTK6 Down-Regulation (Caenorhabditis elegans)
PTK6 Down-Regulation (Danio rerio)
PTK6 Down-Regulation (Mus musculus)
PTK6 Down-Regulation (Rattus norvegicus)
PTK6 Down-Regulation (Sus scrofa)
PTK6 Down-Regulation (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-16)
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