SRMS phosphorylates PTK6

Stable Identifier
R-HSA-8849102
Type
Reaction
Species
Homo sapiens
Compartment
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Protein tyrosine kinase SRMS phosphorylates PTK6 (BRK) on a C-terminal tyrosine residue Y447, resulting in the inhibition of PTK6 kinase activity. In vitro, SRMS can phosphorylate PTK6 at Y447 in the absence of PTK6 autophosphorylation at Y342. It is not known if SRMS directly binds to PTK6 (Fan et al. 2015).

Literature References
PubMed ID Title Journal Year
25897081 Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase

Fan, G, Yang, M, Aleem, S, Miller, WT, Tonks, NK

J. Biol. Chem. 2015
Participants
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Catalyst Activity

protein tyrosine kinase activity of SRMS [cytosol]

Orthologous Events
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