Protein tyrosine kinase SRMS phosphorylates PTK6 (BRK) on a C-terminal tyrosine residue Y447, resulting in the inhibition of PTK6 kinase activity. In vitro, SRMS can phosphorylate PTK6 at Y447 in the absence of PTK6 autophosphorylation at Y342. It is not known if SRMS directly binds to PTK6 (Fan et al. 2015).
Fan, G, Yang, M, Aleem, S, Miller, WT, Tonks, NK
protein tyrosine kinase activity of SRMS [cytosol]
© 2022 Reactome
