SRMS phosphorylates PTK6

Stable Identifier
R-HSA-8849102
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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SRMS phosphorylates PTK6
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Protein tyrosine kinase SRMS phosphorylates PTK6 (BRK) on a C-terminal tyrosine residue Y447, resulting in the inhibition of PTK6 kinase activity. In vitro, SRMS can phosphorylate PTK6 at Y447 in the absence of PTK6 autophosphorylation at Y342. It is not known if SRMS directly binds to PTK6 (Fan et al. 2015).

Literature References
PubMed ID Title Journal Year
25897081 Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase

Fan, G, Aleem, S, Yang, M, Miller, WT, Tonks, NK

J. Biol. Chem. 2015
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of SRMS [cytosol]
Physical Entity
SRMS [cytosol]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
SRMS phosphorylates PTK6 (Bos taurus)
SRMS phosphorylates PTK6 (Caenorhabditis elegans)
SRMS phosphorylates PTK6 (Danio rerio)
SRMS phosphorylates PTK6 (Mus musculus)
SRMS phosphorylates PTK6 (Rattus norvegicus)
SRMS phosphorylates PTK6 (Sus scrofa)
SRMS phosphorylates PTK6 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-12)