Reactome | RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex

RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex

Stable Identifier

R-HSA-8849350

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex

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Retrograde tubule formation may depend on the minus-end directed dynein-dynactin motor complex, which is recruited to the Golgi through interaction with both RAB6 and BICD (Short et al, 2002; Hoogenraad et al, 2001; Matanis et al, 2002; Young et al, 2005; Januschke et al, 2007). Interaction of dynein:dynactin with RAB6:GTP activates the motor protein by displacing the PAFAH1B1 protein, which otherwise keeps the motor "idling" (Yamada et al, 2013; reviewed in Heffernan and Simpson, 2014).

Literature References

PubMed ID	Title	Journal	Year
15483056	Regulation of microtubule-dependent recycling at the trans-Golgi network by Rab6A and Rab6A' Young, J, Stauber, T, del Nery, E, Vernos, I, Pepperkok, R, Nilsson, T	Mol. Biol. Cell	2005
12447383	Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex Matanis, T, Akhmanova, A, Wulf, P, del Nery, E, Weide, T, Stepanova, T, Galjart, N, Grosveld, F, Goud, B, De Zeeuw, CI, Barnekow, A, Hoogenraad, CC	Nat. Cell Biol.	2002
11483508	Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes Hoogenraad, CC, Akhmanova, A, Howell, SA, Dortland, BR, De Zeeuw, CI, Willemsen, R, Visser, P, Grosveld, F, Galjart, N	EMBO J.	2001
23783758	Rab6a releases LIS1 from a dynein idling complex and activates dynein for retrograde movement Yamada, M, Kumamoto, K, Mikuni, S, Arai, Y, Kinjo, M, Nagai, T, Tsukasaki, Y, Watanabe, TM, Fukui, M, Jin, M, Toba, S, Hirotsune, S	Nat Commun	2013
12401177	The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes Short, B, Preisinger, C, Schaletzky, J, Kopajtich, R, Barr, FA	Curr. Biol.	2002
17827179	Rab6 and the secretory pathway affect oocyte polarity in Drosophila Januschke, J, Nicolas, E, Compagnon, J, Formstecher, E, Goud, B, Guichet, A	Development	2007
25233431	The trials and tubule-ations of Rab6 involvement in Golgi-to-ER retrograde transport Heffernan, LF, Simpson, JC	Biochem. Soc. Trans.	2014