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APLP2 [platelet alpha granule membrane]
Stable Identifier
R-HSA-8848898
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
platelet alpha granule membrane
Synonyms
Amyloid-like protein 2, APLP2_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Surface deployment of platelet alpha granule membrane components (Homo sapiens)
Platelet alpha granule membrane components that are released on degranulation [platelet alpha granule membrane] (Homo sapiens)
APLP2 [platelet alpha granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q06481 APLP2
Gene Names
APLP2, APPL2
Chain
signal peptide:1-31, chain:32-763
Reference Genes
BioGPS Gene:334 APLP2
COSMIC (genes):APLP2 APLP2
CTD Gene:334 APLP2
dbSNP Gene:334 APLP2
ENSEMBL:ENSG00000084234 APLP2
ENSEMBL_homo_sapiens_GENE:ENSG00000084234.18 APLP2
HGNC:598 APLP2
KEGG Gene (Homo sapiens):334 APLP2
Monarch:334 APLP2
NCBI Gene:334 APLP2
OMIM:104776 APLP2
UCSC:Q06481 APLP2
Reference Transcript
RefSeq:NM_001142278.1 APLP2
RefSeq:NM_001142276.1 APLP2
RefSeq:NM_001243299.1 APLP2
RefSeq:NM_001642.2 APLP2
RefSeq:NM_001142277.1 APLP2
Other Identifiers
11730788_a_at
11738036_s_at
11741085_a_at
11741086_x_at
16733435
208248_PM_x_at
208248_x_at
208702_PM_x_at
208702_x_at
208703_PM_s_at
208703_s_at
208704_PM_x_at
208704_x_at
211404_PM_s_at
211404_s_at
214875_PM_x_at
214875_x_at
334
3356116
3356117
3356118
3356119
3356120
3356130
3356131
3356132
3356136
3356137
3356138
3356139
3356140
3356141
3356143
3356150
3356152
3356153
3356154
3356155
3356157
3356158
3356162
3356163
3356165
3356169
3356170
3356171
3356172
3356173
3356174
33944_at
7945182
A_14_P103531
A_14_P106265
A_23_P202939
A_24_P300952
GE81049
GO:0003677
GO:0004867
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005783
GO:0005788
GO:0005886
GO:0007186
GO:0007409
GO:0007417
GO:0008201
GO:0012505
GO:0016020
GO:0023052
GO:0030154
GO:0030414
GO:0031092
GO:0031410
GO:0042802
GO:0043226
GO:0046872
GO:0046914
GO:0048856
GO:0070062
GO:0098772
HMNXSV003035374
Hs.279518.1.S2_3p_a_at
Hs.279518.4.S1_3p_a_at
ILMN_1710482
L09209_s_at
PH_hs_0014354
TC11001194.hg
TC11002955.hg
g13325115_3p_a_at
g4502146_3p_a_at
Participates
as a member of
Platelet alpha granule membrane components that are released on degranulation [platelet alpha granule membrane] (Homo sapiens)
Other forms of this molecule
APLP2 [endoplasmic reticulum lumen]
p-APLP2 [endoplasmic reticulum lumen]
APLP2 [plasma membrane]
Inferred To
Appl [platelet alpha granule membrane]
(Drosophila melanogaster)
APLP2 [platelet alpha granule membrane]
(Bos taurus)
APLP2 [platelet alpha granule membrane]
(Caenorhabditis elegans)
APLP2 [platelet alpha granule membrane]
(Canis familiaris)
APLP2 [platelet alpha granule membrane]
(Gallus gallus)
APLP2 [platelet alpha granule membrane]
(Mus musculus)
APLP2 [platelet alpha granule membrane]
(Rattus norvegicus)
APLP2 [platelet alpha granule membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001135748.1
,
NP_001135750.1
,
NP_001633.1
,
NP_001230228.1
,
NP_001135749.1
OpenTargets
ENSG00000084234
GeneCards
Q06481
HPA
ENSG00000084234-APLP2
Ensembl
ENSP00000263575
,
ENSP00000497691
,
ENST00000528499
,
ENSP00000435914
,
ENSP00000263574
,
ENST00000278756
,
ENST00000650012
,
ENST00000345598
,
ENSP00000278756
,
ENST00000338167
,
ENST00000263574
,
ENSG00000084234
,
ENSP00000345444
PRO
Q06481
Pharos - Targets
Q06481
PDB
5JBT
,
5TPT
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05412 JUN
4
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
0.573
3
UniProt:O00213 APBB1
1
APBB1 [nucleoplasm]
(R-HSA-5683987)
0.547
3
UniProt:P05067-4 APP
2
APP (535-695) [cytosol]
(R-HSA-9839084)
APP [mitochondrial inner membrane]
(R-HSA-9839060)
0.544
2
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