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APLP2 [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-8956784
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
Amyloid-like protein 2, APLP2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Post-translational protein phosphorylation (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
APLP2 [endoplasmic reticulum lumen] (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
APLP2 [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q06481 APLP2
Gene Names
APLP2, APPL2
Chain
signal peptide:1-31, chain:32-763
Reference Genes
BioGPS Gene:334 APLP2
COSMIC (genes):APLP2 APLP2
COSMIC (genes):APPL2 APLP2
CTD Gene:334 APLP2
dbSNP Gene:334 APLP2
ENSEMBL:ENSG00000084234 APLP2
HGNC:598 APLP2
KEGG:hsa:334 APLP2
Monarch:334 APLP2
NCBI Gene:334 APLP2
OMIM:104776 APLP2
UCSC:Q06481 APLP2
Reference Transcript
RefSeq:NM_001142276.1 APLP2
RefSeq:NM_001642.2 APLP2
RefSeq:NM_001142278.1 APLP2
RefSeq:NM_001243299.1 APLP2
RefSeq:NM_001142277.1 APLP2
Participates
as a member of
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
Other forms of this molecule
APLP2 [plasma membrane]
APLP2 [platelet alpha granule membrane]
p-APLP2 [endoplasmic reticulum lumen]
Inferred To
Appl [endoplasmic reticulum lumen]
(Drosophila melanogaster)
APLP2 [endoplasmic reticulum lumen]
(Bos taurus)
APLP2 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
APLP2 [endoplasmic reticulum lumen]
(Canis familiaris)
APLP2 [endoplasmic reticulum lumen]
(Gallus gallus)
APLP2 [endoplasmic reticulum lumen]
(Mus musculus)
APLP2 [endoplasmic reticulum lumen]
(Rattus norvegicus)
APLP2 [endoplasmic reticulum lumen]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000338167
,
ENST00000528499
,
ENST00000278756
,
ENSP00000278756
,
ENSP00000345444
,
ENSP00000263574
,
ENST00000263574
,
ENSP00000263575
,
ENSP00000435914
,
ENSP00000497691
,
ENST00000650012
,
ENST00000345598
,
ENSG00000084234
OpenTargets
ENSG00000084234
GeneCards
APLP2
HPA
ENSG00000084234-APLP2
PRO
Q06481
Pharos - Targets
Q06481
GlyGen
Q06481
PDB
5JBT
,
8RQ6
,
5TPT
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.573
3
UniProt:O00213 APBB1
1
APBB1 [nucleoplasm]
(R-HSA-5683987)
0.547
3
UniProt:P05067-4 APP
2
APP [mitochondrial inner membrane]
(R-HSA-9839060)
APP (535-695) [cytosol]
(R-HSA-9839084)
0.544
2
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