Reactome | APLP2 [plasma membrane]

APLP2 [plasma membrane]

Stable Identifier

R-HSA-8848902

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Amyloid-like protein 2, APLP2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q06481 APLP2

Gene Names

APLP2, APPL2

Chain

signal peptide:1-31, chain:32-763

Reference Genes

BioGPS Gene:334 APLP2

COSMIC (genes):APLP2 APLP2

COSMIC (genes):APPL2 APLP2

CTD Gene:334 APLP2

dbSNP Gene:334 APLP2

ENSEMBL:ENSG00000084234 APLP2

HGNC:598 APLP2

KEGG:hsa:334 APLP2

Monarch:334 APLP2

NCBI Gene:334 APLP2

OMIM:104776 APLP2

UCSC:Q06481 APLP2

Reference Transcript

Participates

as a member of

Platelet alpha granule membrane components that are released on degranulation [plasma membrane] (Homo sapiens)

Other forms of this molecule

APLP2 [endoplasmic reticulum lumen]

p-APLP2 [endoplasmic reticulum lumen]

APLP2 [platelet alpha granule membrane]

Inferred To

APLP2 [plasma membrane] (Bos taurus)

APLP2 [plasma membrane] (Canis familiaris)

APLP2 [plasma membrane] (Gallus gallus)

APLP2 [plasma membrane] (Sus scrofa)

Aplp2 [plasma membrane] (Mus musculus)

Aplp2 [plasma membrane] (Rattus norvegicus)

apl-1 [plasma membrane] (Caenorhabditis elegans)

aplp2 [plasma membrane] (Danio rerio)

Appl [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001230228.1, NP_001135748.1, NP_001135750.1, NP_001633.1, NP_001135749.1

OpenTargets

ENSG00000084234

ENSEMBL

ENST00000263574, ENSP00000497691, ENST00000345598, ENSP00000435914, ENSG00000084234, ENSP00000278756, ENST00000278756, ENST00000528499, ENST00000650012, ENSP00000263575, ENSP00000263574, ENSP00000345444, ENST00000338167

HPA

ENSG00000084234-APLP2

GeneCards

APLP2

PRO

Q06481

Pharos - Targets

Q06481

GlyGen

Q06481

PDB

5JBT, 5TPT, 8RQ6

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.573	3
UniProt:Q9HCM2 PLXNA4	2	p-Y-PLXNA4 [plasma membrane] (R-HSA-419608) PLXNA4 [plasma membrane] (R-HSA-399736)	0.558	2
UniProt:O00213 APBB1	1	APBB1 [nucleoplasm] (R-HSA-5683987)	0.547	3
UniProt:P05067-4 APP	2	APP [mitochondrial inner membrane] (R-HSA-9839060) APP (535-695) [cytosol] (R-HSA-9839084)	0.544	2

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