Expression of PPARA

Stable Identifier
R-HSA-879724
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of PPARA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The PPARA gene is transcribed to yield mRNA and the mRNA is translated to yield protein. As inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) heterodimers bind E-box elements in the second intron of the PPARA gene and activate transcription of PPARA.
Literature References
PubMed ID Title Journal Year
19710929 Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human

Rakhshandehroo, M, Hooiveld, G, Muller, M, Kersten, S

PLoS One 2009
7981125 Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators

Mukherjee, R, Jow, L, Noonan, D, McDonnell, DP

J Steroid Biochem Mol Biol 1994
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
positive regulation of transcription by RNA polymerase II (0045944)
This event is regulated
Positively by
Regulator
p-S90-BMAL1:p-T451,T461-CLOCK:PPARA gene [nucleoplasm] (Homo sapiens)
Regulator
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Ppara (Mus musculus)
Authored
May, B  (2010-06-18)
Reviewed
D'Eustachio, P  (2009-05-27)
Albrecht, U  (2010-06-23)
Kay, SA  (2010-06-23)
Hirota, T  (2010-06-23)
Delaunay, F  (2010-06-23)
Kersten, S  (2009-06-08)
Albrecht, U  (2025-03-06)
Created
May, B  (2010-06-23)
Cite Us!