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Regulation of IFNG signaling
Stable Identifier
R-HSA-877312
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon gamma signaling (Homo sapiens)
Regulation of IFNG signaling (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
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PDF
SVG
|
PNG
Low
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PPTX
|
SBGN
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At least three different classes of negative regulators exist to control the extent of INFG stimulation and signaling. These include the feedback inhibitors belonging to protein family suppressors of cytokine signaling (SOCS), the Scr-homology 2 (SH2)-containing protein tyrosine phosphatases (SHPs), and the protein inhibitors of activated STATs (PIAS). The induction of these regulators seems to be able to stop further signal transduction by inhibiting various steps in IFNG cascade.
Literature References
PubMed ID
Title
Journal
Year
10526574
Negative regulators of cytokine signal transduction
Hilton, DJ
Cell Mol Life Sci
1999
18031232
PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and transcription
Palvimo, JJ
Biochem Soc Trans
2007
12645661
Suppressors of cytokine signalling: SOCS
Röpke, C
,
Larsen, L
APMIS
2002
Participants
Events
SOCS-1 and SOCS-3 binds to p-JAK2
(Homo sapiens)
Dephosphorylation of JAKs by PTPs
(Homo sapiens)
PIAS1 binds p-STAT1 dimer
(Homo sapiens)
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP
(Homo sapiens)
Participates
as an event of
Interferon gamma signaling (Homo sapiens)
Event Information
Go Biological Process
regulation of type II interferon-mediated signaling pathway (0060334)
Orthologous Events
Regulation of IFNG signaling (Bos taurus)
Regulation of IFNG signaling (Caenorhabditis elegans)
Regulation of IFNG signaling (Canis familiaris)
Regulation of IFNG signaling (Danio rerio)
Regulation of IFNG signaling (Drosophila melanogaster)
Regulation of IFNG signaling (Gallus gallus)
Regulation of IFNG signaling (Mus musculus)
Regulation of IFNG signaling (Rattus norvegicus)
Regulation of IFNG signaling (Sus scrofa)
Cross References
BioModels Database
BIOMD0000000477
Authored
Garapati, P V (2010-06-08)
Reviewed
Abdul-Sater, AA (2010-08-17)
Schindler, C (2010-08-17)
Created
Garapati, P V (2010-06-11)
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