Beta oxidation of hexanoyl-CoA to butanoyl-CoA

Stable Identifier
R-HSA-77350
Type
Pathway
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Click the image above or here to open this pathway in the Pathway Browser
The sixth pass through the beta-oxidation spiral picks up where the last left off with the saturated fatty acid hexanoyl-CoA and produces butanoyl-CoA. Four enzymatic steps are required starting with SCAD CoA dehydrogenase (Short Chain) activity, followed by the enoyl-CoA hydratase activity of crotonase, the 3-hydroxyacyl-CoA dehydrogenase activity of the short chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD), and completed by the ketoacyl-CoA thiolase activity, present in the mitochondrial membrane associated trifunctional protein.
Literature References
PubMed ID Title Journal Year
  The Metabolic and Molecular Bases of Inherited Disease, 8th ed

Beaudet, AL, Scriver, CR, Sly, WS, Valle, D

  2001
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
fatty acid beta-oxidation (0006635)
Orthologous Events
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (Bos taurus)
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (Caenorhabditis elegans)
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (Canis familiaris)
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (Danio rerio)
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (Dictyostelium discoideum)
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (Drosophila melanogaster)
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (Gallus gallus)
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (Mus musculus)
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (Rattus norvegicus)
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (Sus scrofa)
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (Xenopus tropicalis)
Authored
Gillespie, ME  (2003-09-19)
Created
Gillespie, ME  (2003-09-19)
Cite Us!