trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA

Stable Identifier
R-HSA-77325
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
(2E)-hexenoyl-CoA + H2O => (3S)-hydroxyhexanoyl-CoA
ReviewStatus
5/5
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trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ECHS1 in the mitochondrial matrix hydrates trans-hex-2-enoyl-CoA to form (S)-3-hydroxyhexanoyl-CoA (Stern & Del Campillo 1956).
Literature References
PubMed ID Title Journal Year
13295248 Enzymes of fatty acid metabolism. II. Properties of crystalline crotonase.

Stern, JR, Del Campillo, A

J Biol Chem 1956
Participants
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Output
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as an event of
Catalyst Activity

enoyl-CoA hydratase activity of ECHS1 hexamer [mitochondrial matrix]

Physical Entity
ECHS1 hexamer [mitochondrial matrix] (Homo sapiens)
Activity
enoyl-CoA hydratase activity (GO:0004300)
Orthologous Events
trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Bos taurus)
trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Caenorhabditis elegans)
trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Canis familiaris)
trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Danio rerio)
trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Dictyostelium discoideum)
trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Drosophila melanogaster)
trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Gallus gallus)
trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Mus musculus)
trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Rattus norvegicus)
trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Sus scrofa)
trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Xenopus tropicalis)
Cross References
RHEA
Created
Gillespie, ME  (2003-09-19)
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