The volatile anesthetic halothane can undergo CYP2E1-catalyzed oxidation to form a reactive intermediate which can acetylate liver proteins. These proteins can then stimulate an immune reaction that mediates severe hepatic necrosis ("halothane hepatitis").
Spracklin, DK, Hankins, DC, Fisher, JM, Thummel, KE, Kharasch, ED
Kharasch, ED, Hankins, D, Mautz, D, Thummel, KE
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