The volatile anesthetic halothane can undergo CYP2E1-catalyzed oxidation to form a reactive intermediate which can acetylate liver proteins. These proteins can then stimulate an immune reaction that mediates severe hepatic necrosis ("halothane hepatitis").
Kharasch, ED, Thummel, KE, Hankins, D, Mautz, D
Kharasch, ED, Spracklin, DK, Hankins, DC, Thummel, KE, Fisher, JM
monooxygenase activity of Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane]
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