Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide

Stable Identifier
R-HSA-76475
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The volatile anesthetic halothane can undergo CYP2E1-catalyzed oxidation to form a reactive intermediate which can acetylate liver proteins. These proteins can then stimulate an immune reaction that mediates severe hepatic necrosis ("halothane hepatitis").

Literature References
PubMed ID Title Journal Year
9103523 Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro

Spracklin, DK, Hankins, DC, Fisher, JM, Thummel, KE, Kharasch, ED

J Pharmacol Exp Ther 1997
8637342 Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis

Kharasch, ED, Hankins, D, Mautz, D, Thummel, KE

Lancet 1996
Participants
Participant Of
hasEvent
Event Information
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane]
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Activity
Orthologous Events
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Created