Reactome | Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide

Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide

Stable Identifier

R-HSA-76475

Type

Reaction [transition]

Species

Homo sapiens

Compartment

smooth endoplasmic reticulum

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Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide

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The volatile anesthetic halothane can undergo CYP2E1-catalyzed oxidation to form a reactive intermediate which can acetylate liver proteins. These proteins can then stimulate an immune reaction that mediates severe hepatic necrosis ("halothane hepatitis").

Literature References

PubMed ID	Title	Journal	Year
9103523	Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro Spracklin, DK, Hankins, DC, Fisher, JM, Thummel, KE, Kharasch, ED	J Pharmacol Exp Ther	1997
8637342	Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis Kharasch, ED, Hankins, D, Mautz, D, Thummel, KE	Lancet	1996