Reactome | CYP2E1 reactions

CYP2E1 reactions

Stable Identifier

R-HSA-211999

Type

Pathway

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

ReviewStatus

5/5

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CYP2E1 can metabolize and activate a large number of solvents and industrial monomers as well as drugs. This quality of CYP2E1 may make it an important determinant of human susceptibility to the toxic effects of industrial and environmental chemicals. Typical CYP2E1 substrates include acetaminophen, benzene, CCl4, halothane, ethanol and vinyl chloride. CYP2E1 contributes to oxidative stress by producing oxidising species called reactive oxygen species (ROS) which can lead to damage to mitochondria, DNA and initiate lipid peroxidation or even cell death.

Literature References

PubMed ID	Title	Journal	Year
15603755	Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1 Gonzalez, FJ	Mutat Res	2005
14744237	Oxidative stress, toxicology, and pharmacology of CYP2E1 Cederbaum, AI, Caro, AA	Annu Rev Pharmacol Toxicol	2004
10397283	Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)--a review Lieber, CS	Alcohol Clin Exp Res	1999