Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Insulin receptor recycling
Stable Identifier
R-HSA-77387
DOI
10.3180/REACT_1109.2
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor recycling (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this pathway in the Pathway Browser
Triggered by acidification of the endosome, insulin dissociates from the receptor and is degraded. The receptor is dephosphorylated and re-integrated into the plasma membrane, ready to be activated again by the binding of insulin molecules.
Participants
Events
ATP6AP1 binds V-ATPase
(Homo sapiens)
Endosome acidification
(Homo sapiens)
Dissociation of insulin from insulin receptor
(Homo sapiens)
Insulin degradation
(Homo sapiens)
Insulin receptor de-phosphorylation
(Homo sapiens)
Re-integration of insulin receptor into plasma membrane
(Homo sapiens)
Participates
as an event of
Signaling by Insulin receptor (Homo sapiens)
Event Information
Go Biological Process
insulin receptor recycling (0038020)
Orthologous Events
Insulin receptor recycling (Bos taurus)
Insulin receptor recycling (Caenorhabditis elegans)
Insulin receptor recycling (Canis familiaris)
Insulin receptor recycling (Danio rerio)
Insulin receptor recycling (Dictyostelium discoideum)
Insulin receptor recycling (Drosophila melanogaster)
Insulin receptor recycling (Gallus gallus)
Insulin receptor recycling (Mus musculus)
Insulin receptor recycling (Plasmodium falciparum)
Insulin receptor recycling (Rattus norvegicus)
Insulin receptor recycling (Saccharomyces cerevisiae)
Insulin receptor recycling (Schizosaccharomyces pombe)
Insulin receptor recycling (Sus scrofa)
Insulin receptor recycling (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000343
,
BIOMD0000000137
,
BIOMD0000000581
,
BIOMD0000000448
,
BIOMD0000000345
Authored
Bevan, AP (2003-07-31)
Created
Bevan, AP (2003-07-31)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text