XDH oxidizes xanthine to form urate

Stable Identifier
R-HSA-74258
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Xanthine + H2O + O2 => Urate + H2O2
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Cytosolic xanthine dehydrogenase (XDH) in its oxidase form catalyzes the reaction of xanthine with H2O and oxygen to form urate and H2O2. The active form of the enzyme is a dimer (Saksela and Raivio 1996; Yamaguchi et al. 2007). The enzyme is said to occur predominantly in its dehydrogenase form, catalyzing the reaction of xanthine with NAD+ to form urate and to be converted to the oxidase form annotated here in response to stress (Ichida et al. 2012).

Participants
Participates
Catalyst Activity

xanthine oxidase activity of XDH dimer [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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