Purine catabolism

Stable Identifier
R-HSA-74259
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Purine catabolism
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The purine bases guanine and hypoxanthine (derived from adenine by events in the purine salvage pathways) are converted to xanthine and then to urate uric acid, which is excreted from the body (Watts 1974). The end-point of this pathway in humans and hominoid primates is unusual. Most other mammals metabolize uric acid further to yield more soluble end products, and much speculation has centered on possible roles for high uric acid levels in normal human physiology.
Literature References
PubMed ID Title Journal Year
4620886 Molecular variation in relation to purine metabolism

Watts, RW

J Clin Pathol Suppl (R Coll Pathol) 1974
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Events
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Event Information
Go Biological Process
purine nucleotide catabolic process (0006195)
Orthologous Events
Purine catabolism (Bos taurus)
Purine catabolism (Caenorhabditis elegans)
Purine catabolism (Canis familiaris)
Purine catabolism (Danio rerio)
Purine catabolism (Dictyostelium discoideum)
Purine catabolism (Drosophila melanogaster)
Purine catabolism (Gallus gallus)
Purine catabolism (Mus musculus)
Purine catabolism (Plasmodium falciparum)
Purine catabolism (Rattus norvegicus)
Purine catabolism (Saccharomyces cerevisiae)
Purine catabolism (Schizosaccharomyces pombe)
Purine catabolism (Sus scrofa)
Purine catabolism (Xenopus tropicalis)
Authored
Jassal, B  (2003-07-17)
Created
Jassal, B  (2003-07-17)
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