dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)

Stable Identifier
R-HSA-74207
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)
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Mitochondrial deoxyguanosine kinase (DGUOK) catalyzes the reactions of deoxyadenosine, deoxyguanosine, and deoxyinosine with ATP to form the corresponding nucleotide monophosphates and ADP (Park and Ives 1988; Johansson and Karlson 1996). Crystallographic studies of the human enzyme have confirmed its dimeric structure and allowed identification of key amino acid residues responsible for its substrate specificity (Johansson et al. 2001).
Literature References
PubMed ID Title Journal Year
8692979 Cloning and expression of human deoxyguanosine kinase cDNA

Johansson, M, Karlsson, A

Proc Natl Acad Sci USA 1996
2845866 Properties of a highly purified mitochondrial deoxyguanosine kinase

Park, I, Ives, DH

Arch Biochem Biophys 1988
11427893 Structural basis for substrate specificities of cellular deoxyribonucleoside kinases

Johansson, K, Ramaswamy, S, Ljungcrantz, C, Knecht, W, Piskur, J, Munch-Petersen, B, Eriksson, S, Eklund, H

Nat Struct Biol 2001
Participants
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Output
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as an event of
Catalyst Activity

deoxynucleoside kinase activity of DGUOK dimer [mitochondrial matrix]

Physical Entity
DGUOK dimer [mitochondrial matrix] (Homo sapiens)
Activity
deoxynucleoside kinase activity (GO:0019136)
Orthologous Events
dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Bos taurus)
dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Canis familiaris)
dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Danio rerio)
dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Dictyostelium discoideum)
dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Gallus gallus)
dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Mus musculus)
dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Rattus norvegicus)
dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Sus scrofa)
dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Xenopus tropicalis)
Created
Jassal, B  (2003-07-17)
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