Reactome | dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)

dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)

Stable Identifier

R-HSA-74207

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)

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Mitochondrial deoxyguanosine kinase (DGUOK) catalyzes the reactions of deoxyadenosine, deoxyguanosine, and deoxyinosine with ATP to form the corresponding nucleotide monophosphates and ADP (Park and Ives 1988; Johansson and Karlson 1996). Crystallographic studies of the human enzyme have confirmed its dimeric structure and allowed identification of key amino acid residues responsible for its substrate specificity (Johansson et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
8692979	Cloning and expression of human deoxyguanosine kinase cDNA Karlsson, A, Johansson, M	Proc Natl Acad Sci USA	1996
2845866	Properties of a highly purified mitochondrial deoxyguanosine kinase Park, I, Ives, DH	Arch Biochem Biophys	1988
11427893	Structural basis for substrate specificities of cellular deoxyribonucleoside kinases Knecht, W, Eklund, H, Piskur, J, Munch-Petersen, B, Ramaswamy, S, Ljungcrantz, C, Eriksson, S, Johansson, K	Nat Struct Biol	2001