acetoacetyl-CoA + CoA <=> 2 acetyl-CoA

Stable Identifier
R-HSA-74181
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
acetoacetyl-CoA + CoA <=> 2 acetyl-CoA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Acetyl-CoA acetyltransferase tetramer (ACAT1) in the mitochondrial matrix catalyzes the reversible reaction of acetoacetyl-CoA and CoA to form two molecules of acetyl-CoA (Middleton et al. 1986).
Literature References
PubMed ID Title Journal Year
3709573 3-Ketothiolase deficiency

Middleton, B, Bartlett, K, Romanos, A, Gomez Vazquez, J, Conde, C, Cannon, RA, Lipson, M, Sweetman, L, Nyhan, WL

Eur J Pediatr 1986
Participants
Input
Output
Participates
as an event of
Event Information
Reverse Reaction
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Homo sapiens)
Catalyst Activity

acetyl-CoA C-acetyltransferase activity of ACAT1 tetramer [mitochondrial matrix]

Physical Entity
ACAT1 tetramer [mitochondrial matrix] (Homo sapiens)
Activity
acetyl-CoA C-acetyltransferase activity (GO:0003985)
Orthologous Events
acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Bos taurus)
acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Caenorhabditis elegans)
acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Canis familiaris)
acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Danio rerio)
acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Dictyostelium discoideum)
acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Drosophila melanogaster)
acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Gallus gallus)
acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Mus musculus)
acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Plasmodium falciparum)
acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Rattus norvegicus)
acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Sus scrofa)
Cross References
RHEA
Created
Gopinathrao, G  (2003-07-16)
Cite Us!