UBF-1 Binds rDNA Promoter

Stable Identifier
R-HSA-73718
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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UBF-1 binds directly to the CORE and UCE elements of the ribosomal DNA promoter. This binding is mediated by the HMG boxes (primarily HMG box1). Phosphorylation may play a role in the modulation of UBF's DNA binding activity, as well as in subsequent steps. UBF is thought to bind DNA in a conformation specific manner (as opposed to a sequence specific manner). The binding of UBF to the minor groove of DNA induces strong DNA bending.

Literature References
PubMed ID Title Journal Year
2330041 Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins.

Jantzen, HM, Bell, SP, Tjian, R

Nature 1990
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This event is regulated
Negatively by
Regulator
Summation

Methylcytosine in the promoter of a rRNA gene binds MBD2 (and possibly other Methyl Domain Binding Proteins) and prevents the transcription factor UBF-1 from binding. In mouse, methylation of the cytosine 133 nucleotides upstream of the start of transcription is sufficient. In the human rRNA promoter methylation of cytosines 9, 102, and 347 nucleotides upstream inhibit transcription.

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