UBF-1 Binds rDNA Promoter

Stable Identifier
R-HSA-73718
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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UBF-1 binds directly to the CORE and UCE elements of the ribosomal DNA promoter. This binding is mediated by the HMG boxes (primarily HMG box1). Phosphorylation may play a role in the modulation of UBF's DNA binding activity, as well as in subsequent steps. UBF is thought to bind DNA in a conformation specific manner (as opposed to a sequence specific manner). The binding of UBF to the minor groove of DNA induces strong DNA bending.

Literature References
PubMed ID Title Journal Year
2330041 Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins.

Jantzen, HM, Bell, SP, Tjian, R

Nature 1990
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