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Eukaryotic Translation Termination
Stable Identifier
R-HSA-72764
DOI
10.3180/REACT_1986.1
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Termination (Homo sapiens)
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The arrival of any of the three stop codons (UAA, UAG and UGA) into the ribosomal A-site triggers the binding of a release factor (RF) to the ribosome and subsequent polypeptide chain release. In eukaryotes, the RF is composed of two proteins, eRF1 and eRF3. eRF1 is responsible for the hydrolysis of the peptidyl-tRNA, while eRF3 provides a GTP-dependent function. The ribosome releases the mRNA and dissociates into its two complex subunits, which can reassemble on another molecule to begin a new round of protein synthesis. It should be noted that at present, there is no factor identified in eukaryotes that would be the functional equivalent of the bacterial ribosome release (or recycling) factor, RRF, that catalyzes dissociation of the ribosome from the mRNA following release of the polypeptide
Literature References
PubMed ID
Title
Journal
Year
15314182
GTP hydrolysis by eRF3 facilitates stop codon decoding during eukaryotic translation termination
Salas-Marco, J
,
Bedwell, DM
Mol Cell Biol
2004
2684966
Molecular cloning and expression of ribosome releasing factor
Ichikawa, S
,
Kaji, A
J Biol Chem
1989
Participants
Events
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer
(Homo sapiens)
GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex
(Homo sapiens)
GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex
(Homo sapiens)
Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex
(Homo sapiens)
APEH hydrolyses NAc-Ser-protein
(Homo sapiens)
Participates
as an event of
Translation (Homo sapiens)
Event Information
Go Biological Process
translational termination (0006415)
Orthologous Events
Eukaryotic Translation Termination (Bos taurus)
Eukaryotic Translation Termination (Caenorhabditis elegans)
Eukaryotic Translation Termination (Canis familiaris)
Eukaryotic Translation Termination (Danio rerio)
Eukaryotic Translation Termination (Dictyostelium discoideum)
Eukaryotic Translation Termination (Drosophila melanogaster)
Eukaryotic Translation Termination (Gallus gallus)
Eukaryotic Translation Termination (Mus musculus)
Eukaryotic Translation Termination (Plasmodium falciparum)
Eukaryotic Translation Termination (Rattus norvegicus)
Eukaryotic Translation Termination (Saccharomyces cerevisiae)
Eukaryotic Translation Termination (Schizosaccharomyces pombe)
Eukaryotic Translation Termination (Sus scrofa)
Eukaryotic Translation Termination (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000293
Authored
Bedwell, DM (2004-11-09)
Created
Merrick, WC (2005-01-03)
Bedwell, DM (2005-01-03)
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