N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer

Stable Identifier
R-HSA-6800138
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Class 1 release factors such as eukaryotic peptide chain release factor subunit 1 (ETF1) direct the termination of peptide translation in response to the termination codons UAA, UAG and UGA. ETF1 needs to be complexed with ERF3 in its GTP-bound form to be efficiently post-translationally methylated. HemK methyltransferase family member 2 (N6AMT1) is a heterodimeric methyltransferase that catalyses N5-methylation of ETF1 on glutamine 185 (Q185), using S-adenosyl L-methionine (AdoMet) as the methyl donor (Figaro et al. 2008). N6AMT1 forms a complex with multifunctional methyltransferase subunit TRM112-like protein (TRMT112)

Literature References
PubMed ID Title Journal Year
18539146 HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1

Figaro, S, Scrima, N, Buckingham, RH, Heurgué-Hamard, V

FEBS Lett. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein-glutamine N-methyltransferase activity of N6AMT1:TRMT112 [cytosol]
Physical Entity
Activity
Orthologous Events
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