Reactome | Aldolase tetramer cleaves F1,6PP

Aldolase tetramer cleaves F1,6PP

Stable Identifier

R-HSA-71496

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate

ReviewStatus

5/5

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Cytosolic aldolase catalyzes the cleavage of D-fructose 1,6-bisphosphate to yield dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate. The active form of aldolase is a homotetramer. Three aldolase isozymes have been identified which differ in their patterns of expression in various adult tissues and during development but are otherwise functionally indistinguishable (Ali and Cox 1995; Freemont et al. 1984, 1988).

Literature References

PubMed ID	Title	Journal	Year
7717389	Diverse mutations in the aldolase B gene that underlie the prevalence of hereditary fructose intolerance Ali, M, Cox, TM	Am J Hum Genet	1995
6696436	Human skeletal-muscle aldolase: N-terminal sequence analysis of CNBr- and o-iodosobenzoic acid-cleavage fragments Freemont, PS, Dunbar, B, Fothergill, LA	Arch Biochem Biophys	1984
3355497	The complete amino acid sequence of human skeletal-muscle fructose-bisphosphate aldolase Dunbar, B, Fothergill-Gilmore, LA	Biochem J	1988