Reactome | Aldolase tetramers convert GA3P and DHAP to F1,6PP

Aldolase tetramers convert GA3P and DHAP to F1,6PP

Stable Identifier

R-HSA-71495

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphate

ReviewStatus

5/5

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Aldolase tetramers convert GA3P and DHAP to F1,6PP

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In this freely reversible cytosolic reaction, DHAP (dihydroxyacetone phosphate) and GA3P (D-glyceraldehyde 3-phosphate) react to form F1,6PP (D-fructose 1,6-bisphosphate). The active form of aldolase, the enzyme that catalyzes the reaction, is a homotetramer. Three aldolase isozymes have been identified which differ in their patterns of expression in various adult tissues and during development but are otherwise functionally indistinguishable (Ali and Cox 1995; Dunbar and Fothergill-Gilmore 1988).

Literature References

PubMed ID	Title	Journal	Year
7717389	Diverse mutations in the aldolase B gene that underlie the prevalence of hereditary fructose intolerance Ali, M, Cox, TM	Am J Hum Genet	1995
3355497	The complete amino acid sequence of human skeletal-muscle fructose-bisphosphate aldolase Dunbar, B, Fothergill-Gilmore, LA	Biochem J	1988