PRODH oxidises L-Pro to 1PYR-5COOH

Stable Identifier
R-HSA-70670
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
proline => L-1-pyrroline-5-carboxylate
Locations in the PathwayBrowser
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The dehydrogenation (oxidation) of proline to L-1-pyrroline-5-carboxylate coupled to the conversion of FAD to FADH2 is the first step in proline breakdown (Bender et al. 2005). Proline dehydrogenase (PRODH), the enzyme that catalyzes this reaction, is found in liver, kidney, and brain cells, where it is tightly bound to the inner mitochondrial membrane.

Literature References
PubMed ID Title Journal Year
15662599 Functional consequences of PRODH missense mutations

Bender, HU, Almashanu, S, Steel, G, Hu, CA, Lin, WW, Willis, A, Pulver, A, Valle, D

Am J Hum Genet 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
proline dehydrogenase activity of PRODH(1-?) [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
Authored