oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]

Stable Identifier
R-HSA-70613
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
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oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mitochondrial aspartate aminotransferase catalyzes the reversible reaction of oxaloacetate and glutamate to form aspartate and 2-oxoglutarate (alpha-ketoglutarate) (Martini et al. 1985). The active form of the enzyme is inferred to be a dimer with one molecule of pyridoxal phosphate associated with each monomer.

Literature References
PubMed ID Title Journal Year
4052435 The primary structure of mitochondrial aspartate aminotransferase from human heart

Martini, F, Angelaccio, S, Barra, D, Pascarella, S, Maras, B, Doonan, S, Bossa, F

Biochim Biophys Acta 1985
Participants
Input
Output
Participant Of
hasEvent
Event Information
Reverse Reaction
GOT2 dimer deaminates L-Asp (Homo sapiens)
Catalyst Activity
Catalyst Activity
Title
L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix]
Physical Entity
GOT2 dimer [mitochondrial matrix]
Activity
L-aspartate:2-oxoglutarate aminotransferase activity (0004069)
Orthologous Events
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Bos taurus)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Caenorhabditis elegans)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Canis familiaris)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Danio rerio)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Dictyostelium discoideum)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Drosophila melanogaster)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Mus musculus)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Rattus norvegicus)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Saccharomyces cerevisiae)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Schizosaccharomyces pombe)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Xenopus tropicalis)
Cross References
Rhea
Reviewed
Harris, RA  (2008-09-10)