oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]

Stable Identifier
R-HSA-70613
Type
Reaction
Species
Homo sapiens
Compartment
mitochondrial matrix
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oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]
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Mitochondrial aspartate aminotransferase catalyzes the reversible reaction of oxaloacetate and glutamate to form aspartate and 2-oxoglutarate (alpha-ketoglutarate) (Martini et al. 1985). The active form of the enzyme is inferred to be a dimer with one molecule of pyridoxal phosphate associated with each monomer.

Literature References
PubMed ID Title Journal Year
4052435 The primary structure of mitochondrial aspartate aminotransferase from human heart

Bossa, F, Maras, B, Barra, D, Pascarella, S, Angelaccio, S, Doonan, S, Martini, F

Biochim Biophys Acta 1985
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Catalyst Activity

L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix]

Physical Entity
GOT2 dimer [mitochondrial matrix] (Homo sapiens)
Activity
L-aspartate:2-oxoglutarate aminotransferase activity (GO:0004069)
Orthologous Events
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Bos taurus)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Caenorhabditis elegans)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Canis familiaris)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Danio rerio)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Dictyostelium discoideum)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Drosophila melanogaster)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Mus musculus)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Plasmodium falciparum)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Rattus norvegicus)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Saccharomyces cerevisiae)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Schizosaccharomyces pombe)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Xenopus tropicalis)
Cross References
Rhea
Reviewed
Harris, RA  (2008-09-10)
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