Reactome | Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs

Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs

Stable Identifier

R-HSA-6811423

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

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Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs

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Retrograde COPI vesicles destined for fusion with the ER are tethered to the ER membrane by interactions with the ER t-SNARE proteins and with the CATCHR ('complexes associated with tethering containing helical rods') complex NRZ (reviewed in Szul and Sztul, 2011; Tagaya et al, 2014). The trimeric NRZ complex, known as Dsl in yeast, is composed of NBAS, RINT1 and ZW10 and is recruited to the ER through association with the ER t-SNAREs USE1L, STX18 and BNIP1 (Hirose et al, 2004; Aoki et al, 2004; Nakajima et al, 2004; Arasaki et al, 2006; Ren et al, 2009; Civril et al, 2010; reviewed in Tagaya et al, 2014). Evidence in yeast suggests components of the Dsl complex also interact with the coatomer coat; these interactions contribute to vesicle fusion both by aiding in the recruitment of the vesicle to the ER membrane and also to the depolymerization of coatomer and thus vesicle uncoating Interactions (Andag et al, 2001; Andag et al, 2003; Reilly et al, 2001; Hsia and Hoelz, 2010; Meiringer et al, 2011; Zink et al, 2009). Note that although this pathway shows COPI vesicles from the Golgi being 'received' exclusively at the ER, vesicles are also tethered and fused at the ERGIC. The SNAREs and tethering complexes that mediate this fusion are not identified.

Literature References

PubMed ID	Title	Journal	Year
15029241	Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi Tagaya, M, Hatsuzawa, K, Takio, K, Tohyama, M, Tani, K, Hirose, H, Arasaki, K, Dohmae, N, Yamamoto, A, Nagahama, M	EMBO J.	2004
15272311	Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion Tagaya, M, Taniguchi, M, Nakajima, K, Tani, K, Hirose, H, Arasaki, K, Yamamoto, A, Nagahama, M, Kurashina, H	EMBO J.	2004
21550981	The Dsl1 protein tethering complex is a resident endoplasmic reticulum complex, which interacts with five soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptors (SNAREs): implications for fusion and fusion regulation Schmitt, HD, Perz, A, Meiringer, CT, Auffarth, K, Ungermann, C, Barlowe, C, Wilson, J, Rethmeier, R	J. Biol. Chem.	2011
25364732	Moonlighting functions of the NRZ (mammalian Dsl1) complex Tagaya, M, Kimura, H, Inoue, H, Arasaki, K	Front Cell Dev Biol	2014
20462495	Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery Grigorean, G, Di Fonzo, A, Wehenkel, A, Ciccarelli, FD, Santaguida, S, Civril, F, Musacchio, A, Giorgi, FM	Structure	2010
20005805	A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1 Yip, CK, Ren, Y, Jeffrey, PD, Tripathi, A, Walz, T, Hughson, FM, Huie, D	Cell	2009
11739780	Golgi-to-endoplasmic reticulum (ER) retrograde traffic in yeast requires Dsl1p, a component of the ER target site that interacts with a COPI coat subunit Waters, MG, Kraynack, BA, VanRheenen, SM, Reilly, BA	Mol. Biol. Cell	2001
19758564	A link between ER tethering and COP-I vesicle uncoating Wenzel, D, Zink, S, Schmitt, HD, Wurm, CA	Dev. Cell	2009
19369418	Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport Tagaya, M, Ichimura, S, Shinkawa, T, Aoki, T, Isobe, T, Itoh, A, Kuramoto, M	Mol. Biol. Cell	2009
20534429	Crystal structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat Hoelz, A, Hsia, KC	Proc. Natl. Acad. Sci. U.S.A.	2010
22013193	COPII and COPI traffic at the ER-Golgi interface Sztul, E, Szul, T	Physiology (Bethesda)	2011
14504276	Dsl1p, an essential component of the Golgi-endoplasmic reticulum retrieval system in yeast, uses the same sequence motif to interact with different subunits of the COPI vesicle coat Schmitt, HD, Andag, U	J. Biol. Chem.	2003
11493604	The coatomer-interacting protein Dsl1p is required for Golgi-to-endoplasmic reticulum retrieval in yeast Schmitt, HD, Andag, U, Neumann, T	J. Biol. Chem.	2001
16571679	RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex Taniguchi, M, Tagaya, M, Tani, K, Arasaki, K	Mol. Biol. Cell	2006