Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs

Stable Identifier
R-HSA-6811423
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
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Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs
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Retrograde COPI vesicles destined for fusion with the ER are tethered to the ER membrane by interactions with the ER t-SNARE proteins and with the CATCHR ('complexes associated with tethering containing helical rods') complex NRZ (reviewed in Szul and Sztul, 2011; Tagaya et al, 2014). The trimeric NRZ complex, known as Dsl in yeast, is composed of NBAS, RINT1 and ZW10 and is recruited to the ER through association with the ER t-SNAREs USE1L, STX18 and BNIP1 (Hirose et al, 2004; Aoki et al, 2004; Nakajima et al, 2004; Arasaki et al, 2006; Ren et al, 2009; Civril et al, 2010; reviewed in Tagaya et al, 2014). Evidence in yeast suggests components of the Dsl complex also interact with the coatomer coat; these interactions contribute to vesicle fusion both by aiding in the recruitment of the vesicle to the ER membrane and also to the depolymerization of coatomer and thus vesicle uncoating Interactions (Andag et al, 2001; Andag et al, 2003; Reilly et al, 2001; Hsia and Hoelz, 2010; Meiringer et al, 2011; Zink et al, 2009). Note that although this pathway shows COPI vesicles from the Golgi being 'received' exclusively at the ER, vesicles are also tethered and fused at the ERGIC. The SNAREs and tethering complexes that mediate this fusion are not identified.
Literature References
PubMed ID Title Journal Year
15029241 Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi

Hirose, H, Arasaki, K, Dohmae, N, Takio, K, Hatsuzawa, K, Nagahama, M, Tani, K, Yamamoto, A, Tohyama, M, Tagaya, M

EMBO J. 2004
15272311 Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion

Nakajima, K, Hirose, H, Taniguchi, M, Kurashina, H, Arasaki, K, Nagahama, M, Tani, K, Yamamoto, A, Tagaya, M

EMBO J. 2004
21550981 The Dsl1 protein tethering complex is a resident endoplasmic reticulum complex, which interacts with five soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptors (SNAREs): implications for fusion and fusion regulation

Meiringer, CT, Rethmeier, R, Auffarth, K, Wilson, J, Perz, A, Barlowe, C, Schmitt, HD, Ungermann, C

J. Biol. Chem. 2011
25364732 Moonlighting functions of the NRZ (mammalian Dsl1) complex

Tagaya, M, Arasaki, K, Inoue, H, Kimura, H

Front Cell Dev Biol 2014
20462495 Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery

Civril, F, Wehenkel, A, Giorgi, FM, Santaguida, S, Di Fonzo, A, Grigorean, G, Ciccarelli, FD, Musacchio, A

Structure 2010
20005805 A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1

Ren, Y, Yip, CK, Tripathi, A, Huie, D, Jeffrey, PD, Walz, T, Hughson, FM

Cell 2009
11739780 Golgi-to-endoplasmic reticulum (ER) retrograde traffic in yeast requires Dsl1p, a component of the ER target site that interacts with a COPI coat subunit

Reilly, BA, Kraynack, BA, VanRheenen, SM, Waters, MG

Mol. Biol. Cell 2001
19758564 A link between ER tethering and COP-I vesicle uncoating

Zink, S, Wenzel, D, Wurm, CA, Schmitt, HD

Dev. Cell 2009
19369418 Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport

Aoki, T, Ichimura, S, Itoh, A, Kuramoto, M, Shinkawa, T, Isobe, T, Tagaya, M

Mol. Biol. Cell 2009
20534429 Crystal structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat

Hsia, KC, Hoelz, A

Proc. Natl. Acad. Sci. U.S.A. 2010
22013193 COPII and COPI traffic at the ER-Golgi interface

Szul, T, Sztul, E

Physiology (Bethesda) 2011
14504276 Dsl1p, an essential component of the Golgi-endoplasmic reticulum retrieval system in yeast, uses the same sequence motif to interact with different subunits of the COPI vesicle coat

Andag, U, Schmitt, HD

J. Biol. Chem. 2003
11493604 The coatomer-interacting protein Dsl1p is required for Golgi-to-endoplasmic reticulum retrieval in yeast

Andag, U, Neumann, T, Schmitt, HD

J. Biol. Chem. 2001
16571679 RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex

Arasaki, K, Taniguchi, M, Tani, K, Tagaya, M

Mol. Biol. Cell 2006
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Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Gallus gallus)
Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Mus musculus)
Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Rattus norvegicus)
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Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Xenopus tropicalis)
Authored
Rothfels, K  (2015-11-09)
Reviewed
Gillespie, ME  (2016-02-02)
Created
Rothfels, K  (2015-11-19)
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