Reactome | ARFGAPs stimulate ARF GTPase activity at the Golgi membrane

ARFGAPs stimulate ARF GTPase activity at the Golgi membrane

Stable Identifier

R-HSA-6811418

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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ARFGAPs stimulate ARF GTPase activity at the Golgi membrane

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The ARFGAP proteins stimulates ARF GTPase activity, promoting the release of the nascent COPI vesicle from the membrane and release of ARF:ADP (Tanigawa et al, 1993; reviewed in Beck et al, 2009; East and Kahn, 2011). Although this reaction shows their dissociation, it is not clear whether ARFGAPs persist on the COPI vesicle after GTP hydrolysis, nor is it known when GBF is released from the nascent COPI vesicle.

Literature References

PubMed ID	Title	Journal	Year
19631211	The COPI system: molecular mechanisms and function Rawet, M, Ravet, M, Wieland, FT, Beck, R, Cassel, D	FEBS Lett.	2009
8253837	Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles Tanigawa, G, Amherdt, M, Rothman, JE, Orci, L, Ravazzola, M, Helms, JB	J. Cell Biol.	1993
20637885	Models for the functions of Arf GAPs Kahn, RA, East, MP	Semin. Cell Dev. Biol.	2011