ARFGAPs stimulate ARF GTPase activity at the Golgi membrane

Stable Identifier
R-HSA-6811418
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane
ReviewStatus
5/5
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ARFGAPs stimulate ARF GTPase activity at the Golgi membrane
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The ARFGAP proteins stimulates ARF GTPase activity, promoting the release of the nascent COPI vesicle from the membrane and release of ARF:ADP (Tanigawa et al, 1993; reviewed in Beck et al, 2009; East and Kahn, 2011). Although this reaction shows their dissociation, it is not clear whether ARFGAPs persist on the COPI vesicle after GTP hydrolysis, nor is it known when GBF is released from the nascent COPI vesicle.
Literature References
PubMed ID Title Journal Year
19631211 The COPI system: molecular mechanisms and function

Beck, R, Rawet, M, Ravet, M, Wieland, FT, Cassel, D

FEBS Lett. 2009
8253837 Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles

Tanigawa, G, Orci, L, Amherdt, M, Ravazzola, M, Helms, JB, Rothman, JE

J. Cell Biol. 1993
20637885 Models for the functions of Arf GAPs

East, MP, Kahn, RA

Semin. Cell Dev. Biol. 2011
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane]

Physical Entity
RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Bos taurus)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Caenorhabditis elegans)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Canis familiaris)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Danio rerio)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Dictyostelium discoideum)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Drosophila melanogaster)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Gallus gallus)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Mus musculus)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Plasmodium falciparum)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Rattus norvegicus)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Saccharomyces cerevisiae)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Schizosaccharomyces pombe)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Sus scrofa)
Authored
Rothfels, K  (2015-11-09)
Reviewed
Gillespie, ME  (2016-02-02)
Created
Rothfels, K  (2015-11-19)
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