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STX16 [trans-Golgi network membrane]
Stable Identifier
R-HSA-6811002
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
trans-Golgi network membrane
Synonyms
Syntaxin-16, Syn16
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Retrograde transport at the Trans-Golgi-Network (Homo sapiens)
ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Homo sapiens)
STX10:STX16:VTI1A:VAMP3:NSF hexamer:SNAPs [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
Fusion of early-endosome derived vesicles at the TGN (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
Fusion of late-endosome derived vesicles at the TGN (Homo sapiens)
RAB9:GTP:p-RABEPK:VAMP3:STX16:STX10:VTI1A:GARP complex:GCC2 dimer:late-endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
SNAPs and NSF hexamer bind cis-SNARE at the TGN (Homo sapiens)
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3:NSF hexamer:SNAPs [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Homo sapiens)
RAB9:GTP:p-RABEPK:VAMP3:STX16:STX10:VTI1A:GARP complex:GCC2 dimer:late-endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
cis-SNARE binds SNAPs and NSF hexamer at the TGN (Homo sapiens)
STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14662 STX16
Gene Names
STX16
Chain
chain:1-325
Reference Genes
BioGPS Gene:8675 STX16
COSMIC (genes):STX16 STX16
CTD Gene:8675 STX16
dbSNP Gene:8675 STX16
ENSEMBL:ENSG00000124222 STX16
ENSEMBL:ENSG00000124222.22 STX16
HGNC:11431 STX16
KEGG Gene (Homo sapiens):8675 STX16
Monarch:8675 STX16
NCBI Gene:8675 STX16
OMIM:603666 STX16
UCSC:O14662 STX16
Reference Transcript
RefSeq:NM_001204868.1 STX16
RefSeq:NM_001001433.2 STX16
RefSeq:NM_003763.5 STX16
RefSeq:NM_001134773.2 STX16
RefSeq:NM_001134772.2 STX16
Other Identifiers
11729195_x_at
11729196_a_at
11729197_a_at
11737824_a_at
11737825_s_at
11745516_a_at
1558249_PM_s_at
1558249_s_at
221499_PM_s_at
221499_s_at
221500_PM_s_at
221500_s_at
221638_PM_s_at
221638_s_at
3891007
3891008
3891009
3891010
3891011
3891012
3891022
3891023
3891024
3891026
3891029
3891032
3891039
3891040
3891041
3891042
3891043
39523_at
40885_s_at
41121_at
65432_at
8063636
8675
AF008937_at
A_14_P113993
A_14_P132857
A_24_P36457
A_24_P936122
A_33_P3332860
GE58311
GE61550
GO:0000139
GO:0000149
GO:0005484
GO:0005515
GO:0005737
GO:0005783
GO:0005794
GO:0005802
GO:0005829
GO:0005925
GO:0006886
GO:0006906
GO:0012505
GO:0015031
GO:0016020
GO:0016192
GO:0019905
GO:0030672
GO:0031201
GO:0031410
GO:0031985
GO:0032456
GO:0032588
GO:0042147
GO:0043226
GO:0043231
GO:0048278
GO:0048471
GO:0060090
GO:0061024
HMNXSV003003087
Hs.102178.1.A2_3p_a_at
Hs.102178.1.A3_3p_a_at
Hs2.412288.1.S1_3p_s_at
ILMN_1741942
ILMN_1803698
PH_hs_0023921
TC20001733.hg
g2352817_3p_a_at
g2352817_3p_s_at
Participates
as an output of
NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Homo sapiens)
ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Homo sapiens)
as a component of
STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A [trans-Golgi network membrane] (Homo sapiens)
Other forms of this molecule
STX16 [Golgi membrane]
Inferred To
tlg2 [trans-Golgi network membrane]
(Schizosaccharomyces pombe)
syn7A [trans-Golgi network membrane]
(Dictyostelium discoideum)
STX16 [trans-Golgi network membrane]
(Bos taurus)
STX16 [trans-Golgi network membrane]
(Canis familiaris)
STX16 [trans-Golgi network membrane]
(Danio rerio)
STX16 [trans-Golgi network membrane]
(Gallus gallus)
STX16 [trans-Golgi network membrane]
(Sus scrofa)
Stx16 [trans-Golgi network membrane]
(Mus musculus)
Stx16 [trans-Golgi network membrane]
(Rattus norvegicus)
Syx16 [trans-Golgi network membrane]
(Drosophila melanogaster)
TLG2 [trans-Golgi network membrane]
(Saccharomyces cerevisiae)
stx16 [trans-Golgi network membrane]
(Xenopus tropicalis)
syx-16 [trans-Golgi network membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001001433.1
,
NP_001128245.1
,
NP_001191797.1
,
NP_003754.2
,
NP_001128244.1
OpenTargets
ENSG00000124222
HPA
ENSG00000124222-STX16
GeneCards
O14662
Ensembl
ENST00000371132
,
ENSP00000348229
,
ENST00000371141
,
ENSG00000124222
,
ENST00000467096
,
ENSP00000350723
,
ENSP00000360183
,
ENST00000358029
,
ENSP00000360173
,
ENSP00000434369
,
ENST00000359617
,
ENSP00000352634
,
ENST00000355957
PRO
O14662
Pharos - Targets
O14662
Orphanet
17721
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95183 VAMP5
0.666
4
UniProt:P50222 MEOX2
0.556
3
UniProt:Q12846 STX4
4
STX4 [plasma membrane]
(R-HSA-181519)
STX4 [phagocytic vesicle membrane]
(R-HSA-2029044)
STX4 [cytosol]
(R-HSA-114505)
p-STX4 [cytosol]
(R-HSA-114681)
0.556
3
UniProt:Q9H115 NAPB
1
NAPB [cytosol]
(R-HSA-5688553)
0.556
3
UniProt:P0DTD8 NS7B
0.527
2
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