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STX16 [trans-Golgi network membrane]
Stable Identifier
R-HSA-6811002
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
trans-Golgi network membrane
Synonyms
Syntaxin-16, Syn16
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Retrograde transport at the Trans-Golgi-Network (Homo sapiens)
ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Homo sapiens)
STX10:STX16:VTI1A:VAMP3:NSF hexamer:SNAPs [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
Fusion of early-endosome derived vesicles at the TGN (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
Fusion of late-endosome derived vesicles at the TGN (Homo sapiens)
RAB9:GTP:p-RABEPK:VAMP3:STX16:STX10:VTI1A:GARP complex:GCC2 dimer:late-endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
SNAPs and NSF hexamer bind cis-SNARE at the TGN (Homo sapiens)
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3:NSF hexamer:SNAPs [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Homo sapiens)
RAB9:GTP:p-RABEPK:VAMP3:STX16:STX10:VTI1A:GARP complex:GCC2 dimer:late-endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
cis-SNARE binds SNAPs and NSF hexamer at the TGN (Homo sapiens)
STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane] (Homo sapiens)
STX16 [trans-Golgi network membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14662 STX16
Gene Names
STX16
Chain
chain:1-325
Reference Genes
COSMIC (genes):STX16 STX16
dbSNP Gene:8675 STX16
ENSEMBL:ENSG00000124222 STX16
Participates
as an output of
NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Homo sapiens)
ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Homo sapiens)
as a component of
STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane] (Homo sapiens)
STX10:STX16:VTI1A [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
STX6:STX16:VTI1A [trans-Golgi network membrane] (Homo sapiens)
Other forms of this molecule
STX16 [Golgi membrane]
Inferred To
tlg2 [trans-Golgi network membrane]
(Schizosaccharomyces pombe)
STX16 [trans-Golgi network membrane]
(Bos taurus)
STX16 [trans-Golgi network membrane]
(Canis familiaris)
STX16 [trans-Golgi network membrane]
(Gallus gallus)
STX16 [trans-Golgi network membrane]
(Sus scrofa)
Stx16 [trans-Golgi network membrane]
(Mus musculus)
Stx16 [trans-Golgi network membrane]
(Rattus norvegicus)
Syx16 [trans-Golgi network membrane]
(Drosophila melanogaster)
TLG2 [trans-Golgi network membrane]
(Saccharomyces cerevisiae)
syn16A [trans-Golgi network membrane]
(Dictyostelium discoideum)
stx16 [trans-Golgi network membrane]
(Xenopus tropicalis)
syx-16 [trans-Golgi network membrane]
(Caenorhabditis elegans)
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95183 VAMP5
0.742
5
UniProt:P54920 NAPA
1
NAPA [cytosol]
(R-HSA-264469)
0.643
3
UniProt:Q9NRW7 VPS45
2
VPS45 [Golgi membrane]
(R-HSA-6811025)
VPS45 [endosome membrane]
(R-HSA-1011607)
0.623
3
UniProt:P50222 MEOX2
0.556
3
UniProt:Q9H115 NAPB
1
NAPB [cytosol]
(R-HSA-5688553)
0.556
3
UniProt:Q12846 STX4
4
STX4 [plasma membrane]
(R-HSA-181519)
STX4 [phagocytic vesicle membrane]
(R-HSA-2029044)
STX4 [cytosol]
(R-HSA-114505)
p-STX4 [cytosol]
(R-HSA-114681)
0.556
3
UniProt:P0DTD8 NS7B
0.527
2
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